Evidence map›Paper›PMID 38284080›Full record

ArticleACS omega2024

Biochemical and Structural Analysis of the Bacterial Enzyme Succinyl-Diaminopimelate Desuccinylase (DapE) from

Emma H Kelley, George Minasov, Katherine Konczak, Ludmilla Shuvalova, Joseph S Brunzelle, Shantanu Shukla, Megan Beulke, Teerana Thabthimthong, Kenneth W Olsen, Nicole L Inniss and 2 more

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Reconstruction and Analysis of a Genome-Scale Metabolic Model ofInternational journal of molecular sciences · 2024
    Article
  3. Frontiers in chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Emma H KelleyDepartment of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States.
George MinasovDepartment of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Katherine KonczakDepartment of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States.ORCID https://orcid.org/0000-0002-2025-0475
Ludmilla ShuvalovaDepartment of Pharmacology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Joseph S BrunzelleNorthwestern Synchrotron Research Center, Life Sciences Collaborative Access Team, Northwestern University, Argonne, Illinois 60439, United States.
Shantanu ShuklaDepartment of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Megan BeulkeDepartment of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States.
Teerana ThabthimthongDepartment of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States.
Kenneth W OlsenDepartment of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States.
Nicole L InnissDepartment of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Karla J F SatchellDepartment of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States.ORCID https://orcid.org/0000-0003-3274-7611
Daniel P BeckerDepartment of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States.ORCID https://orcid.org/0000-0001-9392-0460
Loyola University Chicago · USNorthwestern University · US

Funding

TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES.75N93022C00035 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SATCHELL, KARLA · 2022 to 2025
$20.7M
NIAID NIH HHS 75N93022C00035NIAID NIH HHS HHSN272201700060C
6 · The paper itself

Abstract

There is an urgent need for new antibiotics given the rise of antibiotic resistance, and succinyl-diaminopimelate desuccinylase (DapE, E.C. 3.5.1.18) has emerged as a promising bacterial enzyme target. DapE from

Identifiers

PMID38284080
PMCPMC10809365
OpenAlexW4390662784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.