Evidence map›Paper›PMID 38283944›Full record

ArticleFrontiers in molecular biosciences2023

Proteomic analysis of holocarboxylase synthetase deficient-MDA-MB-231 breast cancer cells revealed the biochemical changes associated with cell death, impaired growth signaling, and metabolism.

Witchuda Sukjoi, Clifford Young, Mitchell Acland, Siraprapa Siritutsoontorn, Sittiruk Roytrakul, Manuela Klingler-Hoffmann, Peter Hoffmann, Sarawut Jitrapakdee

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In one paragraph

Article in Frontiers in molecular biosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Biotin Homeostasis and Human Disorders: Recent Findings and Perspectives.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Witchuda SukjoiDepartment of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
Clifford YoungClinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Mitchell AclandAdelaide Proteomics Centre, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia.
Siraprapa SiritutsoontornDepartment of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
Sittiruk RoytrakulFunctional Proteomics Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Agency, Pathumthani, Thailand.
Manuela Klingler-HoffmannClinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Peter HoffmannClinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Sarawut JitrapakdeeDepartment of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously shown that the holocarboxylase synthetase (HLCS) is overexpressed in breast cancer tissue of patients, and silencing of its expression in triple-negative cancer cell line inhibits growth and migration. Here we investigated the global biochemical changes associated with HLCS knockdown in MDA-MB-231 cells to discern the pathways that involve HLCS. Proteomic analysis of two independent HLCS knockdown cell lines identified 347 differentially expressed proteins (DEPs) whose expression change > 2-fold (

Indexed as

biotin carboxylasesbreast cancerholocarboxylase synthetasemetabolismproteomics

Identifiers

PMID38283944
PMCPMC10812114

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.