In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
20 authors at 5 institutions in 1 country.
Huikun WangNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8556-3504 Rodolfo J FloresNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-7911-9228 Hector E YarurNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8549-3315 Aaron LimogesNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-7987-7045 Hector Bravo-RiveraNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7882-3945 Sanne M CaselloNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0910-1110 Niharika LoombaNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-3235-9707 Juan Enriquez-TrabaNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7387-3433 Miguel ArenivarNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0970-3269 Queenie WangNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Robert GanleyMolecular Genetics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Charu RamakrishnanDepartments of Bioengineering and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3474-6332 Lief E FennoDepartments of Bioengineering and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-5237-6179 Yoon KimDepartments of Bioengineering and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Karl DeisserothDepartments of Bioengineering and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0001-9440-3967 Grace OrDepartment of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, USA.
Chunyang DongDepartment of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, USA.
Mark A HoonMolecular Genetics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8794-1684 Lin TianDepartment of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, USA.
Hugo A TejedaNeuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-2222-6222 National Institutes of Health · USStanford University · USUniversity of California, Davis · USDell Children's Medical Center of Central Texas · USMax Planck Florida Institute for Neuroscience · US
Funding
Unit of Neuromodulation and Synaptic IntegrationZIAMH002970 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI TEJEDA, HUGO · 2019 to 2025
$11.1MIntramural NIH HHS ZIA MH002970
6 · The paper itselfAbstract
Prefrontal cortical (PFC) circuits provide top-down control of threat reactivity. This includes ventromedial PFC (vmPFC) circuitry, which plays a role in suppressing fear-related behavioral states. Dynorphin (Dyn) has been implicated in mediating negative affect and mal-adaptive behaviors induced by severe threats and is expressed in limbic circuits, including the vmPFC. However, there is a critical knowledge gap in our understanding of how vmPFC Dyn-expressing neurons and Dyn transmission detect threats and regulate expression of defensive behaviors. Here, we demonstrate that Dyn cells are broadly activated by threats and release Dyn locally in the vmPFC to limit passive defensive behaviors. We further demonstrate that vmPFC Dyn-mediated signaling promotes a switch of vmPFC networks to a fear-related state. In conclusion, we reveal a previously unknown role of vmPFC Dyn neurons and Dyn neuropeptidergic transmission in suppressing defensive behaviors in response to threats via state-driven changes in vmPFC networks.
Identifiers
PMID38283686
PMCPMC10822088
OpenAlexW4390722201
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