Evidence map›Paper›PMID 38283685›Full record

ArticleFrontiers in neurology2023

High indirect bilirubin levels as an independent predictor of postoperative myasthenic crisis: a single-center, retrospective study.

Chao Sun, Zhe Ruan, Yu Zhang, Rongjing Guo, Huanhuan Li, Tantan Wang, Ting Gao, Yonglan Tang, Na Song, Sijia Hao and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Chao Sun *Department of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Zhe Ruan *Department of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Yu Zhang *Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Rongjing GuoDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Huanhuan LiDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Tantan WangSchool of Pharmaceutical Sciences, Peking-Tsinghua Center for Life Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, China.
Ting GaoDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Yonglan TangDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Na SongDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Sijia HaoDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Xiaoxi HuangDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Shuang LiDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Fan NingDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Yue SuDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Qiang LuDepartment of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Qingqing WangDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Xiangqi CaoDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Zhuyi LiDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Ting ChangDepartment of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Thymectomy is an efficient and standard treatment strategy for patients with myasthenia gravis (MG), postoperative myasthenic crisis (POMC) is the major complication related to thymectomy and has a strongly life-threatening effect. As a biomarker, whether the bilirubin level is a risk factor for MG progression remains unclear. This study aimed to investigate the association between the preoperative bilirubin level and postoperative myasthenic crisis (POMC). Methods: We analyzed 375 patients with MG who underwent thymectomy at Tangdu Hospital between January 2012 and September 2021. The primary outcome measurement was POMC. The association between POMC and bilirubin level was analyzed by restricted cubic spline (RCS). Indirect bilirubin (IBIL) was divided into two subgroups based on the normal upper limit of IBIL, 14 μmol/L. Results: Compared with non-POMC group, IBIL levels were significantly higher in patients with POMC. Elevated IBIL levels were closely associated with an increased risk of POMC ( Conclusion: High preoperative IBIL levels, especially those exceeding the normal upper limit, could independently predict the incidence of POMC.

Indexed as

autoimmunebiomarkerindirect bilirubinpostoperative myasthenic crisisreactive oxygen species

Identifiers

PMID38283685
PMCPMC10811789

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