Evidence map›Paper›PMID 38283342›Full record

ArticleFrontiers in immunology2023

Characterization of CD4

Adèle Mangelinck, Agathe Dubuisson, Etienne Becht, Sandra Dromaint-Catesson, Manon Fasquel, Nicolas Provost, Dawid Walas, Hélène Darville, Jean-Pierre Galizzi, Céline Lefebvre and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

  1. Generation of effector CD4Stem cell reports · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Adèle Mangelinck *Servier, Research and Development, Gif-sur-Yvette, France.
Agathe Dubuisson *Servier, Research and Development, Gif-sur-Yvette, France.
Etienne BechtServier, Research and Development, Gif-sur-Yvette, France.
Sandra Dromaint-CatessonServier, Research and Development, Gif-sur-Yvette, France.
Manon FasquelServier, Research and Development, Gif-sur-Yvette, France.
Nicolas ProvostServier, Research and Development, Gif-sur-Yvette, France.
Dawid WalasServier, Research and Development, Gif-sur-Yvette, France.
Hélène DarvilleServier, Research and Development, Gif-sur-Yvette, France.
Jean-Pierre GalizziServier, Research and Development, Gif-sur-Yvette, France.
Céline LefebvreServier, Research and Development, Gif-sur-Yvette, France.
Véronique BlancServier, Research and Development, Gif-sur-Yvette, France.
Vincent LombardiServier, Research and Development, Gif-sur-Yvette, France.
Servier (France) · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The Mixed Lymphocyte Reaction (MLR) consists in the allogeneic co-culture of monocytes derived dendritic cells (MoDCs) with T cells from another donor. This Methods: Here, we used multiplex cytokine and chemokine assays, multiparametric flow cytometry and single cell RNA sequencing to deeply characterize T cells activation and function in the context of CD4 Results: We showed that CD4 Conclusion: These results provide a deep understanding of the kinetics of the MLR assay for CD4

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFlow CytometryLymphocyte Culture Test, MixedSequence Analysis, RNAcell-cell communicationimmune checkpointimmuno-oncologymixed lymphocyte reactionsingle cell RNA sequencingT cells

Identifiers

PMID38283342
PMCPMC10820991
OpenAlexW4390790080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.