Evidence map›Paper›PMID 38282910›Full record

ArticleClinical and translational radiation oncology2024

Rate of pachymeningeal failure following adjuvant WBRT vs SRS in patients with brain metastases.

Enrique Gutierrez-Valencia, Aristotelis Kalyvas, Kurl Jamora, Kaiyun Yang, Ruth Lau, Benazir Khan, Barbara-Ann Millar, Normand Laperriere, Tatiana Conrad, Alejandro Berlin and 6 more

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In one paragraph

Article in Clinical and translational radiation oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Enrique Gutierrez-ValenciaDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Aristotelis KalyvasDivision of Neurosurgery, Toronto Western Hospital - University of Toronto, Toronto, ON, Canada.
Kurl JamoraDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Kaiyun YangDivision of Neurosurgery, Toronto Western Hospital - University of Toronto, Toronto, ON, Canada.
Ruth LauDivision of Neurosurgery, Toronto Western Hospital - University of Toronto, Toronto, ON, Canada.
Benazir KhanDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Barbara-Ann MillarDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Normand LaperriereDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Tatiana ConradDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Alejandro BerlinDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Jessica WeissDepartment of Biostatistics, Princess Margaret Cancer Centre, Toronto, ON, Canada.
Xuan LiDepartment of Biostatistics, Princess Margaret Cancer Centre, Toronto, ON, Canada.
Gelareh ZadehDivision of Neurosurgery, Toronto Western Hospital - University of Toronto, Toronto, ON, Canada.
Mark BernsteinDivision of Neurosurgery, Toronto Western Hospital - University of Toronto, Toronto, ON, Canada.
Paul KongkhamDivision of Neurosurgery, Toronto Western Hospital - University of Toronto, Toronto, ON, Canada.
David B ShultzDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Stereotactic radiosurgery (SRS) has supplanted whole brain radiotherapy (WBRT) as standard-of-care adjuvant treatment following surgery for brain metastasis (BrM). Concomitant with the adoption of adjuvant SRS, a new pattern of failure termed "Pachymeningeal failure" (PMF) has emerged. Methods: We reviewed a prospective registry of 264 BrM patients; 145 and 119 were treated adjuvantly with WBRT and SRS, respectively. The Cox proportional hazards model was used to identify variables correlating to outcomes. Outcomes were calculated using the cumulative incidence (CI) method. Univariate (UVA) and multivariate analyses (MVA) were done to identify factors associated with PMF. Results: CI of PMF was 2 % and 18 % at 12 months, and 2 % and 23 % at 24 months for WRBT and SRS, respectively (p < 0.001) Conclusions: Preoperative dural contact and adjuvant SRS instead of adjuvant WBRT were associated with an increased risk of PMF. Strategies to improve pachymeningeal radiation coverage to sterilize at risk pachymeninges should be investigated.

Indexed as

Leptomeningeal diseasePachymeningeal failurePreoperative dural contact

Identifiers

PMID38282910
PMCPMC10821534

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.