Evidence map›Paper›PMID 38282449›Full record

ArticleWomen's health (London, England)

Prospective cohort study of vitamin D deficiency in pregnancy: Prevalence and limited effectiveness of 1000 IU vitamin D supplementation.

Rasha Mohammed Abdelmageed, Suha Majeed Mohammed Hussein, Shamil Mohamed Anamangadan, Rola Walid Mahmoud Abdullah, Lubna Rauf, AlAnoud Saleh AlFehaidi, Ehab Hamed

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Women's health (London, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rasha Mohammed AbdelmageedQatar University Health Centre, Primary Health Care Corporation, Doha, Qatar.
Suha Majeed Mohammed HusseinQatar University Health Centre, Primary Health Care Corporation, Doha, Qatar.
Shamil Mohamed AnamangadanQatar University Health Centre, Primary Health Care Corporation, Doha, Qatar.
Rola Walid Mahmoud AbdullahQatar University Health Centre, Primary Health Care Corporation, Doha, Qatar.
Lubna RaufQatar University Health Centre, Primary Health Care Corporation, Doha, Qatar.
AlAnoud Saleh AlFehaidiQatar University Health Centre, Primary Health Care Corporation, Doha, Qatar.
Ehab HamedQatar University Health Centre, Primary Health Care Corporation, Doha, Qatar.ORCID 0000-0002-4404-1424
Primary Health Care · QA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D deficiency is highly prevalent worldwide among pregnant women. Although vitamin D supplementation is effective in improving vitamin D status, the safety and optimal dosing of vitamin D supplementation during pregnancy remain less well understood.

objectiveThis study aimed to investigate the prevalence of vitamin D deficiency among pregnant women and evaluate the effectiveness of vitamin D supplementation in improving vitamin D status during pregnancy.

designThis prospective cohort study assessed the impact of a 16-week daily vitamin D supplementation 1000 IU regimen on vitamin D status among pregnant women.

methodsA total of 365 pregnant women were recruited, and their baseline total circulating 25-hydroxy vitamin D concentrations were measured. Of these, 249 participants completed the study, which involved oral daily supplementation with 1000 IU of vitamin D and a repeat of total circulating 25-hydroxy vitamin D concentrations after 16 weeks.

resultsThe study found that 57.7% of the participants had vitamin D deficiency, consistent with the rates reported in other studies. However, vitamin D supplementation at a dose of 1000 IU had a small effect size and was not clinically significant. However, 67% of participants with vitamin D deficiency remained deficient; among participants initially with vitamin D insufficiency, 30% became deficient. Moreover, 26.5% of individuals with sufficient vitamin D status at 12 weeks showed insufficient levels by 28 weeks.

conclusionVitamin D deficiency is widespread among pregnant women, and vitamin D supplementation at a daily dose of 1000 IU may not adequately address this problem. Although the study has limitations, its results align with previous research and may apply to other populations with a high prevalence of vitamin D deficiency during pregnancy. Further research is necessary to determine the most effective approach for addressing prenatal vitamin D deficiency.

Indexed as

Dietary SupplementsVitamin D DeficiencyFemaleHumansPregnancyPrevalenceProspective StudiesVitamin DVitaminsVitamin DVitaminspregnant womenvitamin D deficiencyvitamin D statusvitamin D supplementation

Identifiers

PMID38282449
PMCPMC10826388
OpenAlexW4391325361

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.