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ArticleDigestive diseases and sciences2024

Burden of Anxiety, Depression and Perceived Stress in Patients with Inflammatory Bowel Disease: A Cohort Study from North India.

Arshdeep Singh, Arshia Bhardwaj, Ashish Tripathi, Mukesh Kumar Ranjan, Dharmatma Singh, Ashi Sachdeva, Mahima Marwah, Kriti Sood Sadana, Namita Bansal, Ramit Mahajan and 3 more

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Article in Digestive diseases and sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Inflammatory bowel disease in south Asia: a scoping review.The lancet. Gastroenterology & hepatology · 2025
    Article
  5. Caregiver burden of IBD patients in Asian Emerging Nations is significant and necessitates attention and resource allocation.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024
    Article
4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Arshdeep SinghDepartment of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, Punjab, 141001, India.
Arshia BhardwajDepartment of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, Punjab, 141001, India.
Ashish TripathiDepartment of Internal Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
Mukesh Kumar RanjanDepartment of Gastroenterology, Chitwan Medical College, Bharatpur, Nepal.
Dharmatma SinghDepartment of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, Punjab, 141001, India.
Ashi SachdevaDepartment of Internal Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
Mahima MarwahDepartment of Internal Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
Kriti Sood SadanaDepartment of Pediatrics, Government Medical College and Rajindra Hospital, Patiala, Punjab, India.
Namita BansalResearch and Development Centre, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
Ramit MahajanDepartment of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, Punjab, 141001, India.
Kirandeep KaurDepartment of Pharmacology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
Vandana MidhaDepartment of Internal Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
Ajit SoodDepartment of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, Punjab, 141001, India. ajitsood10@gmail.com.ORCID http://orcid.org/0000-0001-6961-6389

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with Inflammatory bowel disease (IBD) are susceptible to psychiatric co-morbidities. We aimed to ascertain the burden of anxiety, depression, and perceived stress in patients with IBD from north India.

methodsConsenting adult patients with an established diagnosis of IBD were enrolled. The enrolled patients filled the Hospital Anxiety and Depression Scale (HADS) and Perceived Stress Scale (PSS) questionnaires. The patient and disease characteristics were analyzed to determine the correlations and predictors of psychiatric comorbidities.

resultsA total of 318 patients (255 UC, 63 CD; mean age 40.13 ± 12.06 years, 168 [52.8%] males; mean partial Mayo score 2.10 ± 2.35; and mean HBI 2.77 ± 2.13) were enrolled. The prevalence of anxiety, depression and moderate to high perceived stress was 14%, 12%, and 41%, respectively. Females had higher mean perceived stress, anxiety and depression scores compared to males. The partial Mayo score (PMS) correlated poorly with anxiety (ρ = 0.083, p = 0.187), depression (ρ = 0.123, p = 0.49) and perceived stress (ρ = 0.169; p = 0.007). The Harvey Bradshaw index (HBI) correlated fairly with anxiety (ρ = 0.336, p = 0.007) and poorly with depression (ρ = 0.287, p = 0.022) and perceived stress (ρ = 0.20; p = 0.117). Younger age (OR 0.93, 95% CI 0.90-0.97; p = 0.001) and hand-grip strength (OR 4.63, 95% CI 1.88-11.42; p = 0.001) predicted anxiety in patients with UC while rural area of residence (OR 4.75, 95% CI 1.03-21.98; p = 0.046) and HBI (OR 1.60, 95% CI 1.12-2.29; p = 0.009) were significant predictors of anxiety in patients with CD.

conclusionPsychiatric comorbidities are common in patients with IBD, with higher prevalence in females. Young adults with UC and sarcopenia; and individuals with active CD living in rural areas are at an increased risk of anxiety.

Indexed as

Colitis, UlcerativeCrohn DiseaseInflammatory Bowel DiseasesPsychological TestsSelf ReportAdultAnxietyCohort StudiesDepressionFemaleHumansMaleMiddle AgedSeverity of Illness IndexStress, PsychologicalYoung AdultAnxietyCrohn’s diseaseDepressionInflammatory bowel diseasePerceived stressSarcopeniaUlcerative colitis

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.