Evidence map›Paper›PMID 38281989›Full record

ArticleOncogene2024

Overcoming resistance to programmed cell death protein 1 (PD-1) blockade with allogeneic invariant natural killer T-cells (iNKT).

Matthew J Hadfield, Howard Safran, Marco A Purbhoo, Joseph E Grossman, Jennifer S Buell, Benedito A Carneiro

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05108623 (A Phase 1, Open-Label Study of the Safety, Tolerability and Preliminary Clinical Activity of Allogeneic Invariant Natural Killer T), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05108623 phase1completednot on this map

A Phase 1, Open-Label Study of the Safety, Tolerability and Preliminary Clinical Activity of Allogeneic Invariant Natural Killer T (iNKT) Cells (agenT-797) as a Single Agent and in Combination With Approved Immune Checkpoint Inhibitors in Patients With Relapsed/ Refractory Solid Tumors

TypeinterventionalSponsorMiNK TherapeuticsRan2022 to 2024Enrolled34ConditionsTumor, SolidArmsagenT-797, Approved ICIs
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Matthew J HadfieldLegorreta Cancer Center at Brown University, Lifespan Cancer Institute, Providence, RI, USA.
Howard SafranLegorreta Cancer Center at Brown University, Lifespan Cancer Institute, Providence, RI, USA.
Marco A PurbhooAgenus, Inc, Lexington, MA, USA.
Joseph E GrossmanAgenus, Inc, Lexington, MA, USA.ORCID 0000-0002-2130-2783
Jennifer S BuellAgenus, Inc, Lexington, MA, USA.ORCID 0000-0001-7405-0076
Benedito A CarneiroLegorreta Cancer Center at Brown University, Lifespan Cancer Institute, Providence, RI, USA. benedito_carneiro@brown.edu.ORCID 0000-0002-5468-1126
Agenus (United States) · USBrown University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer is the 5

Indexed as

AdenocarcinomaHematopoietic Stem Cell TransplantationNatural Killer T-CellsStomach NeoplasmsHumansProgrammed Cell Death 1 ReceptorProgrammed Cell Death 1 Receptor

Identifiers

PMID38281989
OpenAlexW4391296406

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.