ArticleBiotechnology for biofuels and bioproducts2024
Isopropanol production via the thermophilic bioconversion of sugars and syngas using metabolically engineered Moorella thermoacetica.
Article in Biotechnology for biofuels and bioproducts, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The potential of syngas as a central mediator for a carbon-agnostic circular economy.Nature communications · 2026Review
- Decoding Solvent Effects in Electrocatalytic Biomass Valorization: Levulinic Acid to γ‑Valerolactone.ACS sustainable chemistry & engineering · 2026Article
- Differential effects of isopropyl alcohol on glucose-induced insulin secretion in INS-1 and MIN6 cells.Pharmacological reports : PR · 2026Article
- Propanol production through microbial fermentation of biomass.Bioresources and bioprocessing · 2025Review
- Article
- Harnessing acetogenic bacteria for one-carbon valorization toward sustainable chemical production.RSC chemical biology · 2024Review
- Isolation and characterization of novel acetogenic Moorella strains for employment as potential thermophilic biocatalysts.FEMS microbiology ecology · 2024Article
- Progresses and challenges of engineering thermophilic acetogenic cell factories.Frontiers in microbiology · 2024Review
- Genetic engineering of a thermophilic acetogen,Frontiers in bioengineering and biotechnology · 2024Article
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Authors and funding
12 authors.
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Abstract
backgroundIsopropanol (IPA) is a commodity chemical used as a solvent or raw material for polymeric products, such as plastics. Currently, IPA production depends largely on high-CO
resultsMoorella thermoacetica, a thermophilic acetogenic microorganism, was genetically engineered to produce IPA. A metabolic pathway related to acetone reduction was selected, and acetone conversion to IPA was achieved via the heterologous expression of secondary alcohol dehydrogenase (sadh) in the thermophilic bacterium. sadh-expressing strains were combined with acetone-producing strains, to obtain an IPA-producing strain. The strain produced IPA as a major product using hexose and pentose sugars as substrates (81% mol-IPA/mol-sugar). Furthermore, IPA was produced from CO, whereas acetate was an abundant byproduct. Fermentation using syngas containing both CO and H
conclusionsThe successful engineering of M. thermoacetica resulted in high IPA production from sugars. M. thermoacetica metabolism showed a high capacity for acetone conversion to IPA in the gaseous substrates, indicating acetone production as the bottleneck in IPA production for further improving the strain. This study provides a platform for IPA production via the metabolic engineering of thermophilic acetogens.
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