Evidence map›Paper›PMID 38281942›Full record

ArticleHarm reduction journal2024

High prevalence of hepatitis B virus susceptibility among persons undergoing community-based hepatitis C virus treatment.

Catherine Campusano, Rachel Kanner, Claire McDonell, Meghan Morris, Maria Duarte, Jennifer C Price

Open access · goldAbstract read
In one paragraph

Article in Harm reduction journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Catherine CampusanoDepartment of Medicine, School of Medicine, University of California, San Francisco, CA, USA. catherine.campusano@northwestern.edu.
Rachel KannerDepartment of Medicine, School of Medicine, University of California, San Francisco, CA, USA.
Claire McDonellDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Meghan MorrisDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Maria DuarteDepartment of Medicine, School of Medicine, University of California, San Francisco, CA, USA.
Jennifer C PriceDepartment of Medicine, School of Medicine, University of California, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

NRSA Hepatology Training GrantT32DK060414 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mandana Khalili, JACQUELYN J. MAHER · 2002 to 2026
$6.8M
STIMULUS - Science & Technology Immersion for Underrepresented Learners in the U.S.R25HL125451 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FUNG, ELLEN B, TREADWELL, MARSHA J · 2015 to 2024
$1.3M
NHLBI NIH HHS R25 HL125451NIDDK NIH HHS T32 DK060414
6 · The paper itself

Abstract

backgroundDue to shared modes of transmission, coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV) is common, and HBV vaccination is recommended for all persons with HCV who remain susceptible to HBV. To identify potential gaps in HBV vaccination among this high-risk population, we aimed to determine the patterns of HBV susceptibility in persons undergoing community-based HCV treatment.

methodsWe performed a cross-sectional study within two community-based HCV treatment programs in an urban US setting. Participants were identified for HCV screening and confirmatory testing via street-outreach recruitment directed at persons experiencing homelessness and currently using drugs. Participants were excluded if HBsAg was reactive. Cohort characteristics were obtained via intake surveys and descriptive analysis was performed by exposure status.

resultsAmong 150 participants without chronic HBV receiving community-based HCV treatment, 43% had evidence of prior HBV infection, 26% were immune from vaccination, and 31% were non-immune. Among the subset of the cohort reporting current injection drug use (IDU) (N = 100), 31% (n = 10) of those aged 24-40 and 47% (n = 23) of those aged 41-57 remained susceptible to HBV infection. By contrast only two participants aged 58-74 were HBV non-immune (11%), with 84% immune due to prior exposure.

conclusionsOur data reflect a high prevalence of HBV susceptibility among persons undergoing community-based HCV treatment. Although younger patients were more likely to be immune due to vaccination, a high proportion remained non-immune to HBV, particularly among those reporting current IDU. Our data reflect a gap in HBV vaccination among younger persons with HCV and suggest a potential role for co-localizing HBV vaccination with community-based HCV screening and treatment.

Indexed as

Hepatitis BHepatitis CCross-Sectional StudiesHepacivirusHepatitis B virusHumansPrevalence

Identifiers

PMID38281942
PMCPMC10823661
OpenAlexW4391295736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.