Evidence map›Paper›PMID 38281906›Full record

SynthesisBMC urology2024

Comparing prostatic artery embolization to surgical and minimally invasive procedures for the treatment of benign prostatic hyperplasia: a systematic review and meta-analysis.

Rachel Altman, Roseanne Ferreira, Camilo Barragan, Naeem Bhojani, Katherine Lajkosz, Kevin C Zorn, Bilal Chughtai, Ganesan Annamalai, Dean S Elterman

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BMC urology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
9.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 18 citations in OpenAlex.

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  18. What Role Does PAE Play in the Management of Prostate Cancer?Cardiovascular and interventional radiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Rachel AltmanDivision of Urology, Department of Surgery, University Health Network, Toronto, ON, Canada.
Roseanne FerreiraDivision of Urology, Department of Surgery, University Health Network, Toronto, ON, Canada.
Camilo BarraganDepartment of Vascular and Interventional Radiology, University Health Network, Mount Sinai Hospital, Toronto, ON, Canada.
Naeem BhojaniDepartment of Surgery, University of Montreal Hospital Center, Montreal, QC, Canada.
Katherine LajkoszDepartment of Biostatistics, University Health Network/Princess Margaret Cancer Centre, Toronto, ON, Canada.
Kevin C ZornDepartment of Surgery, University of Montreal Hospital Center, Montreal, QC, Canada.
Bilal ChughtaiDepartment of Urology, Weill Cornell Medical College, New York, NY, USA.
Ganesan AnnamalaiDepartment of Vascular and Interventional Radiology, University Health Network, Mount Sinai Hospital, Toronto, ON, Canada.
Dean S EltermanDivision of Urology, Department of Surgery, University Health Network, Toronto, ON, Canada. dean.elterman@uhn.ca.
University Health Network · CAUniversité de Montréal · CACornell University · USUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo summarize current evidence to report a comparative systematic review and meta-analysis of prostatic artery embolization (PAE) with transurethral resection of the prostate (TURP) and open simple prostatectomy (OSP) for the treatment of benign prostatic hyperplasia (BPH).

methodsA systematic literature search was performed to identify studies published from inception until August 2021. The search terms used were (prostate embolization OR prostatic embolization) AND (prostatic hyperplasia OR prostatic obstruction) as well as the abbreviations of PAE and BPH. Risk of bias was assessed using the Cochrane Risk of Bias tool for randomized controlled trials (RCTs) and the Risk of Bias in Non-randomized Studies-of Interventions (ROBINS-I) tool for observational studies. Random-effects meta-analysis was performed using Revman 5.4.

resultsSeven studies were included with 810 patients: five RCTs and one observational study compared PAE with TURP, and one observational study compared PAE with OSP. The included studies had considerable risk of bias concerns. TURP and OSP were associated with more statistically significant improvements in urodynamic measures and BPH symptoms compared to PAE. However, PAE seems to significantly improve erectile dysfunction compared to OSP and improve other outcome measures compared to TURP, although not significantly. PAE appeared to reduce adverse events and report more minor complications compared with TURP and OSP, but it is unclear whether PAE is more effective in the long-term.

conclusionPAE is an emerging treatment option for patients with symptomatic BPH who cannot undergo surgery or have undergone failed medical therapy. Overall, PAE groups reported fewer adverse events. Future ongoing and longer-term studies are needed to provide better insight into the benefit of PAE compared to other treatment options.

Indexed as

Embolization, TherapeuticLower Urinary Tract SymptomsProstatic HyperplasiaTransurethral Resection of ProstateArteriesHumansMaleMinimally Invasive Surgical ProceduresObservational Studies as TopicProstateTreatment OutcomeBenign prostatic hyperplasiaLower urinary tract symptomsMinimally invasiveOpen simple prostatectomyProstatic artery embolizationTransurethral resection of the prostate

Identifiers

PMID38281906
PMCPMC10822184
OpenAlexW4391287922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.