Evidence map›Paper›PMID 38281680›Full record

ArticleEuropean journal of pharmacology2024

Phenanthroline relaxes uterine contractions induced by diverse contractile agents by decreasing cytosolic calcium concentration.

Mingzi Qu, Ping Lu, Lawrence M Lifshitz, Tiffany A Moore Simas, Ellen Delpapa, Ronghua ZhuGe

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mingzi QuDepartment of Microbiology and Physiological Systems, UMass Chan Medical School, 363 Plantation St., Worcester, MA, USA.
Ping LuDepartment of Microbiology and Physiological Systems, UMass Chan Medical School, 363 Plantation St., Worcester, MA, USA.
Lawrence M LifshitzProgram in Molecular Medicine, UMass Chan Medical School, 373 Plantation St., Worcester, MA, USA.
Tiffany A Moore SimasDepartment of Obstetrics and Gynecology, UMass Chan Medical School/UMass Memorial Health, 119 Belmont St, Worcester, MA, USA.
Ellen DelpapaDepartment of Obstetrics and Gynecology, UMass Chan Medical School/UMass Memorial Health, 119 Belmont St, Worcester, MA, USA. Electronic address: ellen.delpapa@umassmemorial.org.
Ronghua ZhuGeDepartment of Microbiology and Physiological Systems, UMass Chan Medical School, 363 Plantation St., Worcester, MA, USA. Electronic address: ronghua.zhuge@umassmed.edu.
UMass Memorial Health Care · USUniversity of Massachusetts Chan Medical School · US

Funding

Uterine bitter taste receptors in pregnancy and preterm labor managementR01HD095539 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ZHUGE, RONGHUA · 2018 to 2022
$1.7M
NICHD NIH HHS R01 HD095539
6 · The paper itself

Abstract

Uterine contractions during labor and preterm labor are influenced by a complex interplay of factors, including hormones and inflammatory mediators. This complexity may contribute to the limited efficacy of current tocolytics for preterm labor, a significant challenge in obstetrics with 15 million cases annually and approximately 1 million resulting deaths worldwide. We have previously shown that the myometrium expresses bitter taste receptors (TAS2Rs) and that their activation leads to uterine relaxation. Here, we investigated whether the selective TAS2R5 agonist phenanthroline can induce relaxation across a spectrum of human uterine contractions and whether the underlying mechanism involves changes in intracellular Ca

Indexed as

Obstetric Labor, PrematureUterine Contraction15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidCalciumDinoprostEndothelin-1FemaleHumansInfant, NewbornMyometriumOxytocinPhenanthrolinesPregnancy15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidCalciumDinoprostEndothelin-1OxytocinPhenanthrolinesBitter taste receptorsPhenanthrolinePreterm birthUterine contractionUterine relaxant

Identifiers

PMID38281680
PMCPMC10939717
OpenAlexW4391265166

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.