Evidence map›Paper›PMID 38281569›Full record

ArticleAmerican journal of ophthalmology2024

Association of Contrast Sensitivity With Eye Disease and Vision-Related Quality of Life.

Kathryn Flaharty, Leslie M Niziol, Maria A Woodward, Angela Elam, Amanda Bicket, Olivia J Killeen, Jason Zhang, Leroy Johnson, Martha Kershaw, Denise A John and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Letter contrast sensitivity validation.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Kathryn FlahartyFrom the University of Michigan Medical School (K.F.), Ann Arbor, Michigan, USA.
Leslie M NiziolDepartment of Ophthalmology and Visual Sciences, University of Michigan (L.M.N., M.A.W., A.E., A.B., O.J.K., J.Z., D.A.J., S.K.W., D.C.M., P.A.N.-C.), Ann Arbor, Michigan, USA.
Maria A WoodwardDepartment of Ophthalmology and Visual Sciences, University of Michigan (L.M.N., M.A.W., A.E., A.B., O.J.K., J.Z., D.A.J., S.K.W., D.C.M., P.A.N.-C.), Ann Arbor, Michigan, USA.
Angela ElamDepartment of Ophthalmology and Visual Sciences, University of Michigan (L.M.N., M.A.W., A.E., A.B., O.J.K., J.Z., D.A.J., S.K.W., D.C.M., P.A.N.-C.), Ann Arbor, Michigan, USA.
Amanda BicketDepartment of Ophthalmology and Visual Sciences, University of Michigan (L.M.N., M.A.W., A.E., A.B., O.J.K., J.Z., D.A.J., S.K.W., D.C.M., P.A.N.-C.), Ann Arbor, Michigan, USA.
Olivia J KilleenDepartment of Ophthalmology and Visual Sciences, University of Michigan (L.M.N., M.A.W., A.E., A.B., O.J.K., J.Z., D.A.J., S.K.W., D.C.M., P.A.N.-C.), Ann Arbor, Michigan, USA.
Jason ZhangDepartment of Ophthalmology and Visual Sciences, University of Michigan (L.M.N., M.A.W., A.E., A.B., O.J.K., J.Z., D.A.J., S.K.W., D.C.M., P.A.N.-C.), Ann Arbor, Michigan, USA.
Leroy JohnsonHamilton Community Health Network (L.J.), Flint, Michigan, USA.
Martha KershawHope Clinic (M.K.), Ypsilanti, Michigan, USA.
Denise A JohnDepartment of Ophthalmology and Visual Sciences, University of Michigan (L.M.N., M.A.W., A.E., A.B., O.J.K., J.Z., D.A.J., S.K.W., D.C.M., P.A.N.-C.), Ann Arbor, Michigan, USA.
Sarah K WoodDepartment of Ophthalmology and Visual Sciences, University of Michigan (L.M.N., M.A.W., A.E., A.B., O.J.K., J.Z., D.A.J., S.K.W., D.C.M., P.A.N.-C.), Ann Arbor, Michigan, USA.
David C MuschDepartment of Ophthalmology and Visual Sciences, University of Michigan (L.M.N., M.A.W., A.E., A.B., O.J.K., J.Z., D.A.J., S.K.W., D.C.M., P.A.N.-C.), Ann Arbor, Michigan, USA; Department of Epidemiology, School of Public Health, University of Michigan (D.C.M.), Ann Arbor, Michigan, USA.
Paula Anne Newman-CaseyDepartment of Ophthalmology and Visual Sciences, University of Michigan (L.M.N., M.A.W., A.E., A.B., O.J.K., J.Z., D.A.J., S.K.W., D.C.M., P.A.N.-C.), Ann Arbor, Michigan, USA. Electronic address: panewman@med.umich.edu.
University of Michigan · USHealth Net · USHOPE Clinic · US

Funding

VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6M
Wilmer Inst. Mentored Clinical Research Scholar ProgramK12EY015025 · NEI · JOHNS HOPKINS UNIVERSITY · PI James T Handa, Harry Alan Quigley · 2003 to 2026
$8.6M
Support, Educate, Empower: The SEE Personalized Glaucoma Coaching Trial: Diversity SupplementR01EY031337 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEWMAN-CASEY, PAULA ANNE · 2020 to 2024
$3.9M
Sustainable Community Clinic Telemedicine-Based Glaucoma ScreeningU01DP006442 · DP · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEWMAN-CASEY, PAULA ANNE · 2019 to 2023
$3.5M
Quantifying and Understanding Glaucoma Eye Drop Medication Instillation and AdherenceR01EB032328 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Stephen Matthew Cain, Paula Anne Newman-Casey · 2022 to 2026
$3.0M
Increasing Eye Care Utilization in Black Americans At High Risk For Glaucoma Using A Community-Engaged and Faith-Based InterventionK23MD016430 · NIMHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELAM, ANGELA R · 2021 to 2024
$678k
Evaluation of retinal imaging as a biomarker of hypertensive effects on cognitive functionR21AG080407 · NIA · OHIO STATE UNIVERSITY · PI KARVONEN-GUTIERREZ, CARRIE ANNE, MOROI, SAYOKO E · 2023 to 2024
$446k
NCCDPHP CDC HHS U01 DP006442NEI NIH HHS K12 EY015025NEI NIH HHS P30 EY007003NEI NIH HHS R01 EY031337NIA NIH HHS R21 AG080407NIBIB NIH HHS R01 EB032328NIMHD NIH HHS K23 MD016430
6 · The paper itself

Abstract

purposeTo investigate contrast sensitivity (CS) as a screening tool to detect eye disease and assess its association with both eye disease and vision-related quality of life.

designCross-sectional study.

methodsSetting and population: Adults receiving care from a free clinic and a Federally Qualified Health Center in Michigan.

main outcome measuresScreening positive for eye disease and Visual Function Questionnaire (VFQ) score. OBSERVATION: Participants received a vision exam reviewed via telemedicine for disease, completed a demographic survey, and the 9-item VFQ. The ability of CS to predict eye disease was explored and area under the curve (AUC) is reported. Logistic and linear regression were used to investigate the continuous effect of CS on the probability of screening positive for eye disease and VFQ score, respectively, adjusting for age and visual acuity.

results1159 included participants were, on average, 54.9 ± 14.5 years old, 62% identified as female, 34% as White, 54% as Black, 10% as Hispanic/Latino, and reported mean VFQ score of 79.7 ± 15.3. CS ranged from 0.00 to 1.95 log units (mean = 1.54 ± 0.24), 21% of eyes had glaucoma, 19% cataract, 6% DR, and 2% AMD. AUCs were 0.53 to 0.73. A 0.3 log unit decrease in better eye CS was associated with increased odds of glaucoma (odds ratio [OR] = 1.35, confidence interval [CI] = 1.09-1.67), cataract (OR = 1.35, CI = 1.05-1.72), DR (OR = 2.05, CI = 1.51-2.77), and AMD (OR = 2.08, CI = 1.10-3.91). A 0.3 log unit increase in better eye CS was associated with a 5.9 unit increase in VFQ.

conclusionWhile CS alone is not sufficient to identify people with eye disease, it is an important measure of visual function that can add value to comprehensive eye screening.

Indexed as

CataractGlaucomaAdultAgedContrast SensitivityCross-Sectional StudiesFemaleHumansMiddle AgedQuality of LifeSickness Impact ProfileSurveys and Questionnaires

Identifiers

PMID38281569
PMCPMC12001291
OpenAlexW4391265171

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.