ArticleNeuroscience bulletin2024
Gating of Social Behavior by Inhibitory Inputs from Hippocampal CA1 to Retrosplenial Agranular Cortex.
Article in Neuroscience bulletin, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Striatal social reward sensitivity predicts trust-related brain responses depending on closeness and depression.Biological psychology · 2026Article
- Essential function of Nr4a2 in subicular development and social novelty.Journal of advanced research · 2026Article
- MRI-compatible soft fiber bioelectronics for multimodal assessment of electrical neural stimulation on whole-brain activation.National science review · 2026Article
- Male-Biased Social Deficits in Chd8Neuroscience bulletin · 2026Article
- Striatal Social Reward Sensitivity Predicts Trust-Related Brain Responses Depending on Closeness and Depression.bioRxiv : the preprint server for biology · 2026Article
- Environmental Enrichment Preserves Retrosplenial Parvalbumin Density and Cognitive Function in Female 5xFAD Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Unique Transcriptomic Cell Types of the Granular Retrosplenial Cortex Are Preserved across Mice and Rats despite Dramatic Changes in Key Marker Genes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Brain circuits that regulate social behavior.Molecular psychiatry · 2025Review
- Dissection of the long-range circuit of the mouse intermediate retrosplenial cortex.Communications biology · 2025Article
- Disrupted functional connectome in a rodent model of autism during social isolation.Frontiers in neural circuits · 2025Article
- A comprehensive review of GABA in autism spectrum disorders: associations, mechanisms, and therapeutic implications.Frontiers in psychiatry · 2025Review
- Special Issue Celebrating the 25Neuroscience bulletin · 2024Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The retrosplenial cortex has been implicated in processing sensory information and spatial learning, with abnormal neural activity reported in association with psychedelics and in mouse and non-human primate models of autism spectrum disorders (ASDs). The direct role of the retrosplenial cortex in regulating social behaviors remains unclear. In this work, we reveal that neural activity in the retrosplenial agranular cortex (RSA), a subregion of the retrosplenial cortex, is initially activated, then quickly suppressed upon social contact. This up-down phase of RSA neurons is crucial for normal social behaviors. Parvalbumin-positive GABAergic neurons in the hippocampal CA1 region were found to send inhibitory projections to the RSA. Blocking these CA1-RSA inhibitory inputs significantly impaired social behavior. Notably, enhancing the CA1-RSA inhibitory input rescued the social behavior defects in an ASD mouse model. This work suggests a neural mechanism for the salience processing of social behavior and identifies a potential target for ASD intervention using neural modulation approaches.
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