Evidence map›Paper›PMID 38281255›Full record

ReviewClinical & experimental metastasis2024

Neoadjuvant therapy for resectable melanoma.

Cimarron E Sharon, Giorgos C Karakousis

Abstract readReview
In one paragraph

Review in Clinical & experimental metastasis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cimarron E SharonDepartment of Surgery, Division of Endocrine and Oncologic Surgery, Hospital of the University of Pennsylvania, Maloney 4 3400 Spruce Street, Philadelphia, PA, 19104, USA. cimarron.sharon@pennmedicine.upenn.edu.ORCID 0000-0002-8398-3297
Giorgos C KarakousisDepartment of Surgery, Division of Endocrine and Oncologic Surgery, Hospital of the University of Pennsylvania, Maloney 4 3400 Spruce Street, Philadelphia, PA, 19104, USA.

Funding

Targeting exosomal PDL1 to improve immunotherapyP50CA261608 · NCI · WISTAR INSTITUTE · PI HERLYN, MEENHARD F · 2021 to 2025
$11.3M
NCI NIH HHS P50 CA261608
6 · The paper itself

Abstract

The standard of care for patients with resectable stage III/IV melanoma classically included upfront resection with adjuvant therapy. However, in more recent years, the amount of systemic therapies available for neoadjuvant use for these patients has increased. This article reviewed clinical trials investigating neoadjuvant therapy for patients with resectable stage III/IV melanoma. The outcomes of these trials have identified optimal treatment regimens to maximise patient response and minimize toxicities. Additionally, the date demonstrate advantages to neoadjuvant treatment compared to adjuvant therapy alone. Further research is needed to utilize a patient's response to neoadjuvant treatment for prognostication and creation of an individualized treatment plan.

Indexed as

MelanomaNeoadjuvant TherapyAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, AdjuvantHumansNeoplasm StagingRandomized Controlled Trials as TopicSkin NeoplasmsImmune therapyMelanomaNeoadjuvant therapy

Identifiers

PMID38281255
PMCPMC11283575

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.