ArticleBMC nephrology2024
The association between C-reactive protein levels and the risk of kidney stones: a population-based study.
Article in BMC nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 16 citations in OpenAlex.
- Inverse association between the C-reactive protein-to-albumin-to-lymphocyte (CALLY) index and kidney stones in US adults: a population-based study.Urolithiasis · 2026Article
- Association between sarcopenic obesity and kidney stones: evidence from a prospective cohort study on the UK Biobank.BMC public health · 2026Article
- Article
- Higher Life's Essential 8 score is associated with lower risk of kidney stones in Chinese adults: a cross-sectional study.BMC public health · 2025Article
- Cross ethnic Mendelian randomization analysis reveals causal relationship between air pollution and risk of kidney stones.Scientific reports · 2025Article
- Associations between multiple inflammatory biomarkers and the risk of developing kidney stones.BMC urology · 2025Article
- Television viewing, oxidative stress, and kidney stone risk in males: a cross-sectional study with mediation analysis of the NHANES data (2011-2018 years).International urology and nephrology · 2025Article
- Association of neutrophil to lymphocyte ratio with all-cause and cardiovascular mortality among individuals with kidney stone disease: result from NHANES, 2007-2018.Frontiers in endocrinology · 2025Article
- Inverse association between prognostic nutritional index and kidney stone prevalence: A population-based study.PloS one · 2025Article
- Association Between the CALLY Index and Kidney Stones: Insights From NHANES 2007-2010.Mediators of inflammation · 2025Article
- Inverse association between serum klotho levels and C-reactive protein levels in the US population: a cross-sectional study.BMC cardiovascular disorders · 2024Article
- Identifying therapeutic targets for kidney stone disease through proteome-wide Mendelian randomization and colocalization analysis.Urolithiasis · 2024Article
- Two distinct phenotypes of calcium oxalate stone formers could imply different long-term risks for renal function.Urolithiasis · 2024Review
- Two distinct phenotypes of calcium oxalate stone formers could imply different long-term risks for renal function.Research square · 2024Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe relationship between C-reactive protein (CRP) and the risk of developing kidney stones is unclear, and we aimed to assess the association between CRP and kidney stones in US adults.
methodsWe used data from NHANES 2007-2010, and we excluded participants who were under 18 years of age and lacked data on CRP and kidney stones. Finally, we included a total of 11,033 participants and performed weighted multivariate regression analysis and subgroup analysis to assess the independent relationship between CRP and kidney stones.
resultsThe mean prevalence of kidney stones among the participants was 9.8%. Notably, as CRP levels increased, the prevalence of kidney stones exhibited a corresponding rise across quartiles (Kidney stones: Quartile 1: 7.59%; Quartile 2: 8.77%; Quartile 3: 9.64%; Quartile 4: 10.89%). CRP was positively associated with the risk of kidney stones (Model 1: OR = 1.09, 95% CI: 1.01-1.18, p = 0.03; Model 2: OR = 1.09, 95% CI: 1.00-1.18, p = 0.03, Model 3: OR = 1.14, 95%CI: 1.02-1.26, p = 0.04). Participants in the highest CRP quartile experienced a 69% increased risk of kidney stones compared to those in the lowest quartile (OR = 1.64, 95% CI: 1.04-2.59, p = 0.03). Notably, interaction tests revealed that gender, BMI, diabetes, hypertension, CKD and smoking or alcohol consumption status did not significantly influence the association between CRP and kidney stones.
conclusionsOur findings reveal a significant association between higher CRP levels and an increased risk of kidney stones. In clinical practice, heightened awareness of CRP as a potential biomarker could aid in risk assessment and management strategies for kidney stone patients.
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