Evidence map›Paper›PMID 38281006›Full record

ArticleRespiratory research2024

Risk factors for long-term invasive mechanical ventilation: a longitudinal study using German health claims data.

Franziska C Trudzinski, Julia D Michels-Zetsche, Benjamin Neetz, Jan Meis, Michael Müller, Axel Kempa, Claus Neurohr, Armin Schneider, Felix J F Herth, Joachim Szecsenyi and 8 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05260853 (Early Detection and Early Intervention Program in High-risk Patients to Avoid Invasive Long-term Ventilation - Prevention of Invasive Ventilation - PRiVENT), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05260853 naunknown statusnot on this map

Early Detection and Early Intervention Program in High-risk Patients to Avoid Invasive Long-term Ventilation - Prevention of Invasive Ventilation - PRiVENT

TypeinterventionalSponsorFelix JF HerthRan2021 to 2024Enrolled1,500ConditionsInvasive Ventilation, WeaningArmsWeaning Board
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Risk factors for prolonged mechanical ventilation in critically ill patients with ischemic stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Franziska C TrudzinskiDepartment of Pneumology and Critical Care, Thoraxklinik Heidelberg gGmbH, Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany. Franziska.Trudzinski@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-0980-7586
Julia D Michels-Zetsche *Department of Pneumology and Critical Care, Thoraxklinik Heidelberg gGmbH, Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany.
Benjamin NeetzDepartment of Pneumology and Critical Care, Thoraxklinik Heidelberg gGmbH, Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany.
Jan MeisInstitute of Medical Biometry, University of Heidelberg, Heidelberg, Germany.
Michael MüllerDepartment of Pneumology and Critical Care, Thoraxklinik Heidelberg gGmbH, Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany.
Axel KempaDepartment of Pneumology and Critical Care, SLK-Klinik Löwenstein, Löwenstein, Germany.
Claus NeurohrDepartment of Pneumology and Respiratory Medicine, Robert-Bosch-Krankenhaus Klinik Schillerhöhe, Gerlingen, Germany.
Armin SchneiderDepartment of Anesthesia and Intensive Care Medicine Waldburg-Zeil Kliniken, Wangen Im Allgäu, Germany.
Felix J F HerthDepartment of Pneumology and Critical Care, Thoraxklinik Heidelberg gGmbH, Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany.
Joachim SzecsenyiDepartment of General Practice and Health Services Research, University Hospital Heidelberg, Heidelberg, Germany.
Elena BiehlerDepartment of General Practice and Health Services Research, University Hospital Heidelberg, Heidelberg, Germany.
Thomas FleischauerDepartment of General Practice and Health Services Research, University Hospital Heidelberg, Heidelberg, Germany.
Michel WensingDepartment of General Practice and Health Services Research, University Hospital Heidelberg, Heidelberg, Germany.
Simone BritschDepartment of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Center Mannheim, Mannheim, Germany.
Janina Schubert-HaackaQua Institute for Applied Quality Improvement and Research in Health Care, Göttingen, Germany.
Thomas GrobeaQua Institute for Applied Quality Improvement and Research in Health Care, Göttingen, Germany.
Timm FrerkaQua Institute for Applied Quality Improvement and Research in Health Care, Göttingen, Germany.
PRiVENT-study group

Funding

Innovation Fund of the Federal Joint Committee (G-BA) 01NVF19023
6 · The paper itself

Abstract

backgroundLong-term invasive mechanical ventilation (IMV) is a major burden for those affected and causes high costs for the health care system. Early risk assessment is a prerequisite for the best possible support of high-risk patients during the weaning process. We aimed to identify risk factors for long-term IMV within 96 h (h) after the onset of IMV.

methodsThe analysis was based on data from one of Germany's largest statutory health insurance funds; patients who received IMV ≥ 96 h and were admitted in January 2015 at the earliest and discharged in December 2017 at the latest were analysed. OPS and ICD codes of IMV patients were considered, including the 365 days before intubation and 30 days after discharge. Long-term IMV was defined as evidence of invasive home mechanical ventilation (HMV), IMV ≥ 500 h, or readmission with (re)prolonged ventilation.

resultsIn the analysis of 7758 hospitalisations, criteria for long-term IMV were met in 38.3% of cases, of which 13.9% had evidence of HMV, 73.1% received IMV ≥ 500 h and/or 40.3% were re-hospitalised with IMV. Several independent risk factors were identified (p < 0.005 each), including pre-diagnoses such as pneumothorax (OR 2.10), acute pancreatitis (OR 2.64), eating disorders (OR 1.99) or rheumatic mitral valve disease (OR 1.89). Among ICU admissions, previous dependence on an aspirator or respirator (OR 5.13), and previous tracheostomy (OR 2.17) were particularly important, while neurosurgery (OR 2.61), early tracheostomy (OR 3.97) and treatment for severe respiratory failure such as positioning treatment (OR 2.31) and extracorporeal lung support (OR 1.80) were relevant procedures in the first 96 h after intubation.

conclusionThis comprehensive analysis of health claims has identified several risk factors for the risk of long-term ventilation. In addition to the known clinical risks, the information obtained may help to identify patients at risk at an early stage. Trial registration The PRiVENT study was retrospectively registered at ClinicalTrials.gov (NCT05260853). Registered at March 2, 2022.

Indexed as

Noninvasive VentilationPancreatitisAcute DiseaseHumansLongitudinal StudiesRespiration, ArtificialRisk FactorsInvasive home mechanical ventilationLong-term invasive mechanical ventilationPredictive modelPrognostic factorsProlonged weaningWeaningWeaning failure

Identifiers

PMID38281006
PMCPMC10821552

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.