Evidence map›Paper›PMID 38280987›Full record

ReviewJournal of nanobiotechnology2024

Recent progress of non-linear topological structure polymers: synthesis, and gene delivery.

Chenfei Wang, Wei He, Feifei Wang, Haiyang Yong, Tao Bo, Dingjin Yao, Yitong Zhao, Chaolan Pan, Qiaoyu Cao, Si Zhang and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chenfei Wang *Department of Dermatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. wangchenfei@fudan.edu.cn.
Wei He *School of Medicine, Anhui University of Science and Technology, Huainan, 232000, Anhui, China.
Feifei Wang *Department of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, 710032, Shaanxi, China.
Haiyang Yong *School of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China.
Tao BoKey Laboratory of Glycoconjugate Research Ministry of Public Health, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Dingjin YaoShanghai EditorGene Technology Co., Ltd, Shanghai, 200000, China.
Yitong ZhaoSchool of Medicine, Anhui University of Science and Technology, Huainan, 232000, Anhui, China.
Chaolan PanDepartment of Dermatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Qiaoyu CaoDepartment of Dermatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Si ZhangKey Laboratory of Glycoconjugate Research Ministry of Public Health, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. zhangsi@fudan.edu.cn.
Ming LiDepartment of Dermatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. mingli@fudan.edu.cn.

Funding

China Postdoctoral Science Foundation GZC20230502Medical Engineering Cross Research Foundation of Shanghai Jiaotong University YG2022ZD010National Natural Science Foundation of China (NSFC) 82303989Shanghai Municipal Natural Science Foundation 22ZR1440800the Clinical Research Special Project of Shanghai Municipal Health Commission 20234Y0209the National Nature Science Foundation 82073422
6 · The paper itself

Abstract

Currently, many types of non-linear topological structure polymers, such as brush-shaped, star, branched and dendritic structures, have captured much attention in the field of gene delivery and nanomedicine. Compared with linear polymers, non-linear topological structural polymers offer many advantages, including multiple terminal groups, broad and complicated spatial architecture and multi-functionality sites to enhance gene delivery efficiency and targeting capabilities. Nevertheless, the complexity of their synthesis process severely hampers the development and applications of nonlinear topological polymers. This review aims to highlight various synthetic approaches of non-linear topological architecture polymers, including reversible-deactivation radical polymerization (RDRP) including atom-transfer radical polymerization (ATRP), nitroxide-mediated polymerization (NMP), reversible addition-fragmentation chain transfer (RAFT) polymerization, click chemistry reactions and Michael addition, and thoroughly discuss their advantages and disadvantages, as well as analyze their further application potential. Finally, we comprehensively discuss and summarize different non-linear topological structure polymers for genetic materials delivering performance both in vitro and in vivo, which indicated that topological effects and nonlinear topologies play a crucial role in enhancing the transfection performance of polymeric vectors. This review offered a promising guideline for the design and development of novel nonlinear polymers and facilitated the development of a new generation of polymer-based gene vectors.

Indexed as

Gene Transfer TechniquesPolymersClick ChemistryPolymerizationTransfectionPolymersGene deliveryNon-linear topological structure polymersNon-viral gene vectorsSynthetic approachesTransfection performance

Identifiers

PMID38280987
PMCPMC10821314

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.