Evidence map›Paper›PMID 38280952›Full record

ArticlePediatric research2024

Cerebrovascular responses to a 90° tilt in healthy neonates.

Nhu N Tran, Jason S Chwa, Kenneth M Brady, Matthew Borzage, Mary-Lynn Brecht, Jessica X Woon, Anna Miner, Carlin A Merkel, Philippe Friedlich, Bradley S Peterson and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Nhu N Tran *Institute for the Developing Mind, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA. ntran@chla.usc.edu.
Jason S Chwa *Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Kenneth M BradyLurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Matthew BorzageFetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Mary-Lynn BrechtSchool of Nursing, University of California, Los Angeles, Los Angeles, CA, USA.
Jessica X WoonDornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA, USA.
Anna MinerKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Carlin A MerkelKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Philippe FriedlichFetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Bradley S PetersonInstitute for the Developing Mind, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
John C WoodKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
University of Southern California · USChildren's Hospital of Los Angeles · USNorthwestern University · USUniversity of California, Los Angeles · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Longitudinal Assessment of Cerebrovascular Autoregulation (CA) and Associations to Neurodevelopmental Delays in Infants and Toddlers with and without Congenital Heart Disease (CHD)K23NR019121 · NINR · CHILDREN'S HOSPITAL OF LOS ANGELES · PI TRAN, NHU · 2021 to 2023
$497k
NCATS NIH HHS UL1 TR001855NINR NIH HHS K23 NR019121
6 · The paper itself

Abstract

backgroundTilts can induce alterations in cerebral hemodynamics in healthy neonates, but prior studies have only examined systemic parameters or used small tilt angles (<90°). The healthy neonatal population, however, are commonly subjected to large tilt angles (≥90°). We sought to characterize the cerebrovascular response to a 90° tilt in healthy term neonates.

methodsWe performed a secondary descriptive analysis on 44 healthy term neonates. We measured cerebral oxygen saturation (rcSO

resultsrcSO

conclusionA 90° tilt induces a decline in rcSO IMPACT: Healthy term neonates (≤14 days old) had decreased cerebral oxygen saturation (~1.1%) and increased cerebral oxygen extraction (~0.01) following a 90° tilt. We detected a significant position-by-time interaction with all physiological parameters measured, suggesting the effect of position varied across consecutive tilts. No prior study has characterized the cerebral oxygen saturation response to a 90° tilt in healthy term neonates.

Indexed as

Cerebrovascular CirculationHeart RateOxygen SaturationBlood PressureBrainFemaleHealthy VolunteersHemodynamicsHumansInfant, NewbornMaleOxygenPostureRespiratory RateSupine PositionOxygen

Identifiers

PMID38280952
PMCPMC11245387
OpenAlexW4391277587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.