ArticleScience China. Life sciences2024
Hi-Tag: a simple and efficient method for identifying protein-mediated long-range chromatin interactions with low cell numbers.
Article in Science China. Life sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 0 citations in OpenAlex.
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- RIVER delivers multimodal gene-directed regulatory interactions across diverse biological contexts with broad application potentials.Science China. Life sciences · 2026Article
- Improving genomic prediction accuracy of complex traits by integrating massive types of functional annotation information.Nature communications · 2026Article
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14 authors at 1 institution in 1 country.
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Abstract
Protein-mediated chromatin interactions can be revealed by coupling proximity-based ligation with chromatin immunoprecipitation. However, these techniques require complex experimental procedures and millions of cells per experiment, which limits their widespread application in life science research. Here, we develop a novel method, Hi-Tag, that identifies high-resolution, long-range chromatin interactions through transposase tagmentation and chromatin proximity ligation (with a phosphorothioate-modified linker). Hi-Tag can be implemented using as few as 100,000 cells, involving simple experimental procedures that can be completed within 1.5 days. Meanwhile, Hi-Tag is capable of using its own data to identify the binding sites of specific proteins, based on which, it can acquire accurate interaction information. Our results suggest that Hi-Tag has great potential for advancing chromatin interaction studies, particularly in the context of limited cell availability.
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