Evidence map›Paper›PMID 38280130›Full record

ArticleGeneral thoracic and cardiovascular surgery2024

Acquired von Willebrand syndrome and post-operative drainage: a comparison of patients with aortic stenosis versus coronary artery disease.

Aleksandar Djordjevic, Vladimir Jovicic, Dejan Lazovic, Dusko Terzic, Jasna Gacic, Masa Petrovic, Aleksandar Matejic, Bojana Salovic, Ivana Radovic, Tanja Jesic-Petrovic and 2 more

Abstract readComparative Study
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In one paragraph

Article in General thoracic and cardiovascular surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Aleksandar DjordjevicDepartment of Cardiac Surgery, University of Clinical Center of Serbia, Belgrade, Serbia.
Vladimir JovicicDepartment of Cardiac Surgery, University of Clinical Center of Serbia, Belgrade, Serbia.
Dejan LazovicDepartment of Cardiac Surgery, University of Clinical Center of Serbia, Belgrade, Serbia.
Dusko TerzicDepartment of Cardiac Surgery, University of Clinical Center of Serbia, Belgrade, Serbia.
Jasna GacicUniversity Hospital Medical Center Bežanijska Kosa, Belgrade, Serbia.
Masa PetrovicFaculty of Medicine, University of Belgrade, dr Subotića Starijeg 8, 11000, Belgrade, Serbia. 5rovicmasa@gmail.com.ORCID http://orcid.org/0000-0003-1709-8449
Aleksandar MatejicFaculty of Medicine, University of Belgrade, dr Subotića Starijeg 8, 11000, Belgrade, Serbia.
Bojana SalovicFaculty of Medicine, University of Belgrade, dr Subotića Starijeg 8, 11000, Belgrade, Serbia.
Ivana RadovicFaculty of Medicine, University of Belgrade, dr Subotića Starijeg 8, 11000, Belgrade, Serbia.
Tanja Jesic-PetrovicPublic Primary Health Care Center Doboj, Doboj, Republic of Srpska, Bosnia and Herzegovina.
Arsen RisticDepartment of Cardiac Surgery, University of Clinical Center of Serbia, Belgrade, Serbia.
Ivan SoldatovicFaculty of Medicine, University of Belgrade, dr Subotića Starijeg 8, 11000, Belgrade, Serbia.
University of Belgrade · RSPublic Health Institute of the Republic of Srpska · BAUniversity Hospital Medical Center Bezanijska kosa · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDegenerative aortic stenosis and coronary artery disease are considered to be the most prevalent cardiovascular diseases in industrialized countries. This study aims to determine the change over time in von Willebrand factor antigen, von Willebrand factor activity, and factor VIII and where there is a correlation with total post-operative drainage.

methodsThe single-center retrospective study included 203 consecutive patients (64.5% male), undergoing coronary artery bypass surgery between March 1, 2019 and June 30, 2020 at the University Clinical Center of Serbia in the Clinic for Cardiac Surgery in Belgrade, Serbia. All patients 18 years or older who presented with isolated, hemodynamically significant aortic stenosis were included. The control group consisted of patients who presented with only coronary artery disease.

resultsBetween patients with only coronary artery disease and patients with coronary artery diseases and aortic stenosis, there was a statistically significant difference between pre-op and 1-month post-op fibrinogen, factor VIII, von Willebrand factor antigen, and von Willebrand factor (p < 0.001), post-op drainage, with overall lower drainage in coronary artery disease patients, and consistent increase in von Willebrand factor antigen, von Willebrand factor activity, and Factor VIII post-operatively in patients with coronary artery diseases and aortic stenosis.

conclusionThis study has shown that there is a correlation between von Willebrand factor antigen, von Willebrand factor activity and total drainage to the level of statistical significance in aortic stenosis patients and in the overall study population.

Indexed as

Aortic Valve StenosisCoronary Artery BypassCoronary Artery DiseaseFactor VIIIvon Willebrand Diseasesvon Willebrand FactorAgedAged, 80 and overBiomarkersDrainageFemaleHumansMaleMiddle AgedRetrospective StudiesSerbiaBiomarkersF8 protein, humanFactor VIIIVon Willebrand antigenvon Willebrand FactorAcquired von Willebrand syndromeAortic stenosisPost-operative drainage

Identifiers

PMID38280130
OpenAlexW4391277481

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.