Evidence map›Paper›PMID 38279906›Full record

ArticleHypertension in pregnancy2024

Trimester and severity of SARS-CoV-2 infection during pregnancy and risk of hypertensive disorders in pregnancy.

Samantha E Parker, Bhavana Annapragada, Idalis A Chestnut, Jessica Fuchs, Annette Lee, Vishakha Sabharwal, Elisha M Wachman, Christina D Yarrington

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension in pregnancy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Samantha E ParkerDepartment of Epidemiology, School of Public Health, Boston University, Boston, MA, USA.
Bhavana AnnapragadaDepartment of Epidemiology, School of Public Health, Boston University, Boston, MA, USA.
Idalis A ChestnutDepartment of Epidemiology, School of Public Health, Boston University, Boston, MA, USA.
Jessica FuchsDepartment of Epidemiology, School of Public Health, Boston University, Boston, MA, USA.
Annette LeeDepartment of Epidemiology, School of Public Health, Boston University, Boston, MA, USA.
Vishakha SabharwalDepartment of Pediatrics, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA.
Elisha M WachmanDepartment of Pediatrics, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA.
Christina D YarringtonDepartment of Obstetrics and Gynecology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA.
Boston University · US

Funding

Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3M
Coronary Heart Disease in Black Women: The Role of Adverse Pregnancy OutcomesK01HL133600 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KELLEHER, SAMANTHA PARKER · 2016 to 2020
$627k
NCATS NIH HHS UL1 TR001430NHLBI NIH HHS K01 HL133600
6 · The paper itself

Abstract

objectiveSARS-CoV-2 infection during pregnancy has been linked with an increased risk of hypertensive disorders of pregnancy (HDP). The aim of this study was to examine how both trimester and severity of SARS-CoV-2 infection impact HDP.

methodsWe conducted a cohort study of SARS-CoV-2-infected individuals during pregnancy (

resultsCompared to a reference cohort from 2018, SARS-CoV-2 infection did not largely increase the risk of HDP (RR: 1.17; CI:0.90, 1.51), but a non-statistically significant higher risk of preeclampsia was observed (RR: 1.33; CI:0.89, 1.98), in our small sample. Among the SARS-CoV-2 cohort, severity was linked with risk of HDP, with infections requiring hospitalization increasing the risk of HDP compared to asymptomatic/mild infections. Trimester of infection was not associated with risk of HDP, but a slight decline in the risk of HDP was observed with later gestational week of infection. Among patients with asymptomatic or mild symptoms, SARS-CoV-2 in the first trimester conferred a higher risk of HDP compared to the third trimester (RR: 1.70; CI:0.77, 3.77), although estimates were imprecise.

conclusionSARS-CoV-2 infection in early pregnancy may increase the risk of HDP compared to infection later in pregnancy.

Indexed as

COVID-19Hypertension, Pregnancy-InducedPre-EclampsiaCohort StudiesFemaleHumansPregnancySARS-CoV-2COVID-19gestational hypertensionpreeclampsiapregnancytrimester

Identifiers

PMID38279906
PMCPMC10962656
OpenAlexW4391277494

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.