Evidence map›Paper›PMID 38279720›Full record

ArticleCurrent drug discovery technologies2024

Immunomodulation Induced in BALB/c Mice after Subacute Exposure to Hydroalcoholic Extract of

Fatemeh Forouzanfar, Seyed Mostafa Moshirian Farahi, Hassan Rakhshandeh, Bahram Memar, Roghayeh Rashidi, Ramin Mahdipour, Bamdad Riahi-Zanjani

Abstract read
PubMed Publisher
In one paragraph

Article in Current drug discovery technologies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Fatemeh ForouzanfarPharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyed Mostafa Moshirian FarahiPharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.
Hassan RakhshandehPharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.
Bahram MemarFaculty of Medicine, Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Roghayeh RashidiPharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.
Ramin MahdipourDepartment of Anatomical Sciences and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Bamdad Riahi-ZanjaniMedical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mashhad University of Medical Sciences · IR

Funding

Mashhad University of Medical Sciences 992058
6 · The paper itself

Abstract

introductionTarragon, with the scientific name of

methodsMice were treated with hydroalcoholic extract of

resultsHET at a high dose significantly could increase the number of white blood cells and lymphocytes compared to the control group. The lymphocyte proliferation in exposure to PHA significantly increased in the HET group at both doses compared to the control group, whilst this index in the presence of LPS increased significantly for the 500 mg/kg-HET group only. Moreover, in the HA and DTH tests, HET significantly increased the proliferation of lymphocytes as compared with the control group. Furthermore, HET significantly increased the amount of IFN-γ parallel to a decrease in the level of IL-4 in compared to the control group.

conclusionBased on our findings, HET has potent immunostimulant characteristics. More investigation into tarragon's potential to be used in the treatment of disorders caused by a weakened immune response should be conducted.

Indexed as

Interferon-gammaMice, Inbred BALB CPlant ExtractsAnimalsArtemisiaCell ProliferationDose-Response Relationship, DrugFemaleHypersensitivity, DelayedImmunomodulating AgentsImmunomodulationInterleukin-4LymphocytesMaleMiceSpleenImmunomodulating AgentsInterferon-gammaInterleukin-4Plant Extractsantioxidantcellular immunityherbaceous plant.humoral immunityimmunomodulatoryTarragon

Identifiers

PMID38279720
OpenAlexW4391252965

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.