Evidence map›Paper›PMID 38279317›Full record

ArticleInternational journal of molecular sciences2024

The Effect of Race/Ethnicity and MED12 Mutation on the Expression of Long Non-Coding RNAs in Uterine Leiomyoma and Myometrium.

Tsai-Der Chuang, Nhu Ton, Shawn Rysling, Drake Boos, Omid Khorram

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Transcriptomic and functional analysis of fibroid extracellular vesicles.Clinical science (London, England : 1979) · 2026
    Article
  5. Review
  6. Article
  7. Differential Expression of Small Non-Coding RNAs in Uterine Leiomyomas.International journal of molecular sciences · 2025
    Article
  8. The in vivo effects of knockdown of long non-coding RNA XIST on fibroid growth and gene expression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tsai-Der ChuangDepartment of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.ORCID 0000-0003-1195-7054
Nhu TonThe Lundquist Institute for Biomedical Innovation, Torrance, CA 90502, USA.
Shawn RyslingThe Lundquist Institute for Biomedical Innovation, Torrance, CA 90502, USA.
Drake BoosThe Lundquist Institute for Biomedical Innovation, Torrance, CA 90502, USA.
Omid KhorramDepartment of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
UCLA Medical Center · USUniversity of California, Los Angeles · US

Funding

Tryptophan metabolism and its role in fibroid pathogenesisR01HD109286 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI OMID A. KHORRAM · 2022 to 2026
$1.9M
Mechanism of Long Non-coding RNAs Action in leiomyomaR01HD100529 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI KHORRAM, OMID A. · 2020 to 2023
$1.7M
Function of Long Non-Coding RNA MD1 in Leiomyoma PathogenesisR03HD101852 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI KHORRAM, OMID A. · 2021 to 2022
$154k
NICHD NIH HHS R01 HD100529NICHD NIH HHS R01 HD109286NICHD NIH HHS R03 HD101852NIH HHS HD100529, HD100529-02S1, HD101852, and HD109286
6 · The paper itself

Abstract

The objective of this study was to elucidate the expression of long non-coding RNA (lncRNA) in leiomyomas (Lyo) and paired myometrium (Myo) and explore the impact of race and MED12 mutation. Fold change analysis (Lyo/paired Myo) indicated the expression of 63 lncRNAs was significantly altered in the mutated group but not in the non-mutated Lyo. Additionally, 65 lncRNAs exhibited an over 1.5-fold change in the Black but not the White group. Fifteen differentially expressed lncRNAs identified with next-generation sequencing underwent qRT-PCR confirmation. Compared with Myo, the expression of

Indexed as

LeiomyomaMediator ComplexRNA, Long NoncodingUterine NeoplasmsEthnicityFemaleHumansMutationMyometriumTranscription FactorsMED12 protein, humanMediator ComplexRNA, Long NoncodingTranscription FactorsleiomyomalncRNAMED12 mutationmiRNArace

Identifiers

PMID38279317
PMCPMC10816284
OpenAlexW4391110537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.