Evidence map›Paper›PMID 38279158›Full record

ArticleLipids in health and disease2024

Triglyceride-glucose index is a risk factor for breast cancer in China: a cross-sectional study.

Jinghua Zhang, Binbin Yin, Ya Xi, Yongying Bai

Abstract read
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Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jinghua Zhang *Department of Clinical Laboratory, Women's Hospital, Zhejiang University School of Medicine, No. 1, Xueshi Road, Hangzhou, 31006, Zhejiang Province, China.
Binbin Yin *Department of Clinical Laboratory, Women's Hospital, Zhejiang University School of Medicine, No. 1, Xueshi Road, Hangzhou, 31006, Zhejiang Province, China.
Ya XiDepartment of Central Laboratory, The Children's Hospital, National Clinical Research Center of Medicine, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310051, China.
Yongying BaiDepartment of Clinical Laboratory, Women's Hospital, Zhejiang University School of Medicine, No. 1, Xueshi Road, Hangzhou, 31006, Zhejiang Province, China. 5515053@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis research delved into the association between the risk of the Chinese population suffering from breast cancer (BC) and the triglyceride-glucose (TyG) index.

methodsA total of 2,111 sufferers with benign breast disease (BBD) and 477 sufferers with BC were enrolled, and their TyG index was measured. Participants with varying TyG index values were categorized into quartiles. Logistic regression analysis was employed to assess the relationship between the TyG index and BC risk. The diagnostic performance of the TyG index for different stages of BC was measured using the receiver operating characteristic (ROC) curve.

resultsThe TyG index of BC sufferers exceeded that of BBD (P < 0.001). A continuous increase in the risk of BC was found to be positively correlated with an ever-increasing TyG index. In the unadjusted model, the risk of getting BC mounted with quartiles of the TyG index growing (P < 0.001). In a logistic regression analysis that included all confounders, the highest quartile of the TyG index was strongly linked to BC risk [1.43 (1.01, 2.02), P < 0.05]. Moreover, with the adjustment of potential confounders, a high TyG index was found to result in a 2.53-fold higher risk of being diagnosed with advanced BC.

conclusionsThe risen TyG index was positively correlated to the heightening risk of BC and had the potential to serve as a promising biomarker for BC. Individuals with a high TyG index ought to be mindful of the heightened risk of BC onset and progression.

Indexed as

Breast NeoplasmsBiomarkersBlood GlucoseChinaCross-Sectional StudiesFemaleGlucoseHumansRisk FactorsTriglyceridesBiomarkersBlood GlucoseGlucoseTriglyceridesBenign breast diseaseBiomarkerBreast cancerInsulin resistanceRiskTriglyceride-glucose index

Identifiers

PMID38279158
PMCPMC10811843

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.