Evidence map›Paper›PMID 38279042›Full record

ArticleActa pharmacologica Sinica2024

Endothelial cell Orai1 is essential for endothelium-dependent contraction of mouse carotid arteries in normotensive and hypertensive mice.

Xiao Li, Zhen-Chuan Lei, Chun Yin Lo, Tsz Yau Jan, Chi Wai Lau, Xiao-Qiang Yao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Store-operated CaAmerican journal of physiology. Lung cellular and molecular physiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiao LiSchool of Biomedical Sciences, Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Zhen-Chuan LeiSchool of Biomedical Sciences, Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Chun Yin LoSchool of Biomedical Sciences, Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Tsz Yau JanSchool of Biomedical Sciences, Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Chi Wai LauSchool of Biomedical Sciences, Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Xiao-Qiang YaoSchool of Biomedical Sciences, Heart and Vascular Institute and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. yao2068@cuhk.edu.hk.
Chinese University of Hong Kong · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelium-dependent contraction (EDC) exists in blood vessels of normotensive animals, but is exaggerated in hypertension. An early signal in EDC is cytosolic Ca

Indexed as

Carotid ArteriesEndothelial CellsEndothelium, VascularHypertensionMice, Inbred C57BLMice, KnockoutORAI1 ProteinTRPC Cation ChannelsAcetylcholineAngiotensin IIAnimalsMaleMiceTRPV Cation ChannelsVasoconstrictionAcetylcholineAngiotensin IIORAI1 ProteinOrai1 protein, mouseTrpc5 protein, mouseTRPC Cation ChannelsTrpv4 protein, mouseTRPV Cation Channelsacetylcholinecarotid arteryendothelium-dependent contractionhypertensionOrai1

Identifiers

PMID38279042
PMCPMC11053128
OpenAlexW4391259719

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.