ArticleCommunications biology2024
Molecular characterization of Fusarium venenatum-based microbial protein in animal models of obesity using multi-omics analysis.
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Current Single-cell Proteins as Ingredients: Functions, Challenges, and Regulatory Frameworks.Journal of microbiology and biotechnology · 2026Review
- Protective Effects ofJournal of microbiology and biotechnology · 2026Article
- Protective Effects ofJournal of microbiology and biotechnology · 2026Article
- Advancing solid-state fermentation with culinary fungi for nutrient-dense, minimally processed, whole-foods and resilient food systems-a narrative review.Frontiers in nutrition · 2026Review
- Extracellular vesicles ofGut microbes · 2025Article
- Enhanced Longevity and Immunity inFood science of animal resources · 2025Article
- Genetic Ablation of the Conidiogenesis Regulator Enhances Mycoprotein Production.Journal of agricultural and food chemistry · 2025Article
- Functional evaluation of synbiotic combination ofCurrent research in food science · 2025Article
- Article
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Authors and funding
8 authors.
Funding
Abstract
Microbial protein, produced by fermentation of Fusarium venenatum is a promising candidate alternative protein source. Previous study has demonstrated its ability to improve hyperlipidemia in rats, yet the related mechanism remains unclear. In this study, we aimed to evaluate the potential of F. venenatum as an alternative protein source and its impact on lipid metabolism using multi-omics analysis. Initial experiments with Caenorhabditis elegans revealed that F. venenatum enhanced longevity, improved immune responses, and reduced lipid metabolism by downregulating fat synthesis-related genes. Subsequently, we conducted experiments with mice on a high-fat diet to confirm the anti-obesity effects of F. venenatum. The groups fed F. venenatum showed improved lipid profiles and reduced hepatic fat accumulation. Furthermore, fecal metabolomic analysis showed higher excretion of primary bile acid and cholesterol in the groups fed F. venenatum which might lead to a decrease in lipid digestion and hepatic fat accumulation. Collectively, this series of experiments revealed the potential of F. venenatum as a sustainable alternative protein and its application as an anti-obesity supplement.
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