ArticleNature metabolism2024
Genetic architecture and biology of youth-onset type 2 diabetes.
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Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
14.3field-weighted citation impact, top 1% of its field
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Type 2 diabetes genetics in 125,000 admixed adults from Mexico City.medRxiv : the preprint server for health sciences · 2026Article
- Gut microbiota and metabolic disease risk in youth.Cell reports. Medicine · 2026Review
- Integrated transcriptome and single-cell sequencing analysis identify blood-pancreas shared lncRNA biomarkers in new-onset T2DM.PloS one · 2026Article
- Genomic Organization, Evolutionary Conservation and Expression ofBiomedicines · 2025Article
- Comparative risk of end-stage renal disease, myocardial infarction and stroke in young and older onset diabetes in UK Biobank.Scientific reports · 2025Article
- Review
- HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes.Cell metabolism · 2025Article
- Young-onset type 2 diabetes-Epidemiology, pathophysiology, and management.Journal of diabetes investigation · 2025Review
- Review
- Exosomal FOXL1 from bone marrow mesenchymal stem cells activates the METTL3/ATXN2L pathway to ameliorate high glucose-induced human retinal microvascular endothelial cell injury.Diabetology & metabolic syndrome · 2025Article
- Diabetes and atrial fibrillation: Causality is still a black-box.International journal of cardiology. Heart & vasculature · 2025Article
- A Unique Phenotype of Maturity-Onset Diabetes of the Young With a Novel Disease-Causing Insulin Gene Variant.JCEM case reports · 2025Article
- Genetic basis of early onset and progression of type 2 diabetes in South Asians.Nature medicine · 2025Article
- Pathophysiology and Treatment of Prediabetes and Type 2 Diabetes in Youth.Diabetes care · 2024Review
- Polygenic risk for obesity and body dissatisfaction: beyond BMI.Pediatric research · 2024Article
- Monogenic Defects of Beta Cell Function: From Clinical Suspicion to Genetic Diagnosis and Management of Rare Types of Diabetes.International journal of molecular sciences · 2024Review
- Association of long noncoding RNA GAS5 gene polymorphism with progression of diabetic kidney disease.International journal of medical sciences · 2024Article
- Effect of SDF-1 and CXCR4 gene variants on the development of diabetic kidney disease.International journal of medical sciences · 2024Article
Corrections and comments
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Authors and funding
18 authors at 13 institutions in 2 countries.
Soo Heon KwakDepartment of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0003-1230-0919
Shylaja SrinivasanDivision of Pediatric Endocrinology, University of California at San Francisco, San Francisco, CA, USA.
Ling ChenCenter for Genomic Medicine, and Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Jennifer ToddDivision of Pediatric Endocrinology, Department of Pediatrics, University of Vermont, Burlington, VT, USA.
Josep M MercaderPrograms in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8494-3660
Elizabeth T JensenDepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jasmin DiversDepartment of Foundations of Medicine, NYU Langone Health, New York, NY, USA.
Amy K MottlDivision of Nephrology and Hypertension, University of North Carolina, Chapel Hill, NC, USA.
Catherine PihokerDepartment of Pediatrics, University of Washington, Seattle, WA, USA.
Rachelle G GandicaNaomi Berrie Diabetes Center, Columbia University Irving Medical Center, New York, NY, USA.
Lori M LaffelJoslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Elvira IsganaitisJoslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Morey W HaymondDepartment of Pediatrics, Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA.
Lynne L LevitskyPediatric Endocrine Division, Department of Pediatrics, Massachusetts General Hospital for Children and Harvard Medical School, Boston, MA, USA.
Toni I PollinDivision of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Jose C FlorezPrograms in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1730-9325
Jason FlannickPrograms in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. flannick@broadinstitute.org.ORCID http://orcid.org/0000-0002-3618-795X
Progress in Diabetes Genetics in Youth (ProDiGY) consortium
Broad Institute · USJoslin Diabetes Center · USChildren's Nutrition Research Center at Baylor College of Medicine · USColumbia University Irving Medical Center · USHarvard University · USMassachusetts General Hospital · USNYU Langone Health · USUniversity of California, San Francisco · USUniversity of Maryland, Baltimore · USUniversity of North Carolina at Chapel Hill · USUniversity of Vermont · USUniversity of Washington · USWake Forest University · US
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MTreatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) StudyU01DK061230 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BRAFFETT, BARBARA HALINA, ZEITLER, PHILIP S. · 2001 to 2019
$231.8MHARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4MZOPOLRESTAT IN NORMOTENSIVE, TYPE 1 DIA WITH INCIPIENT NEPHROPATHYM01RR000043 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZAIA, JOHN A · 1985 to 2010
$76.4MUNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9MINSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3MYALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7MSPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI Alessandro Doria · 1986 to 2026
$50.5MInstitute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4MWashington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4MHSRD VA HIR 10-001NCATS NIH HHS UL1 TR000062NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR000154NCATS NIH HHS UL1 TR000423NCATS NIH HHS UL1 TR001425NCATS NIH HHS UL1 TR001450NCATS NIH HHS UM1 TR004528NCCDPHP CDC HHS U01 DP000244NCCDPHP CDC HHS U01 DP000246NCCDPHP CDC HHS U01 DP000247NCCDPHP CDC HHS U01 DP000248NCCDPHP CDC HHS U01 DP000250NCCDPHP CDC HHS U01 DP000254NCCDPHP CDC HHS U18 DP002708NCCDPHP CDC HHS U18 DP002709NCCDPHP CDC HHS U18 DP002710NCCDPHP CDC HHS U18 DP002714NCCDPHP CDC HHS U18 DP006131NCCDPHP CDC HHS U18 DP006133NCCDPHP CDC HHS U18 DP006134NCCDPHP CDC HHS U18 DP006136NCCDPHP CDC HHS U18 DP006138NCCDPHP CDC HHS U18 DP006139NCRR NIH HHS M01 RR000036NCRR NIH HHS M01 RR000043NCRR NIH HHS M01 RR000069NCRR NIH HHS M01 RR000084NCRR NIH HHS M01 RR000125NCRR NIH HHS M01 RR001066NCRR NIH HHS M01 RR014467NCRR NIH HHS UL1 RR024134NCRR NIH HHS UL1 RR024139NCRR NIH HHS UL1 RR024153NCRR NIH HHS UL1 RR024989NCRR NIH HHS UL1 RR024992NCRR NIH HHS UL1 RR025758NCRR NIH HHS UL1 RR025780NHGRI NIH HHS U01 HG011723NHGRI NIH HHS U54 HG003067NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K24 HL157960NHLBI NIH HHS N01 HC025195NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG033193NICHD NIH HHS U24 HD112205NIDDK NIH HHS K23 DK120932NIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30 DK057516NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK125490NIDDK NIH HHS R03 DK138213NIDDK NIH HHS U01 DK061212NIDDK NIH HHS U01 DK061230NIDDK NIH HHS U01 DK061239NIDDK NIH HHS U01 DK061242NIDDK NIH HHS U01 DK061254NIDDK NIH HHS U01 DK085526NIDDK NIH HHS U01 DK105554NIDDK NIH HHS UC4 DK108173NIDDK NIH HHS UM1 DK078616NINDS NIH HHS R01 NS017950
Abstract
The prevalence of youth-onset type 2 diabetes (T2D) and childhood obesity has been rising steadily
Indexed as
Diabetes Mellitus, Type 2Pediatric ObesityAdolescentAdultBiologyChildExomeFemaleGenome-Wide Association StudyHumansMale
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.