ArticleNature communications2024
Uncovering supramolecular chirality codes for the design of tunable biomaterials.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Circularly polarized luminescence as a contingency assay for 'mirror life' bio-hazards.Royal Society open science · 2026Article
- Amino Acid Directed Helical Assemblies of Natural Berberine for Chirality-Dependent Photodynamic Antibacterial Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Supramolecular chiral inversion and regulation of phenylalanine-based organogels in low-polarity achiral solvents.Communications chemistry · 2025Article
- Amplification of Asymmetry via Structural Transitions in Supramolecular Polymer-Surfactant Coassemblies.Journal of the American Chemical Society · 2025Article
- Structural Insights Into Amyloid Polymorphism: The Impact of Glutamine to Norleucine Substitutions in GNNQQNY Aggregation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- 2D Interfacial Crystallization Stabilized by Short-Chain Aliphatic Interfaces.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Synthetic chitin oligosaccharide nanocrystals and their higher-order assemblies.Chemical science · 2025Article
- Editorial: Supramolecular cancer therapeutic biomaterials-volume II.Frontiers in chemistry · 2025Article
- Interplay of Stereochemistry and Charge Governs Guest Binding in Flexible ZnJournal of the American Chemical Society · 2024Article
- Chirality and pH Influence the Self-Assembly of Antimicrobial Lipopeptides with Diverse Nanostructures.ACS applied bio materials · 2024Article
- Chiral inversion induced by aromatic interactions in short peptide assembly.Nature communications · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
In neurodegenerative diseases, polymorphism and supramolecular assembly of β-sheet amyloids are implicated in many different etiologies and may adopt either a left- or right-handed supramolecular chirality. Yet, the underlying principles of how sequence regulates supramolecular chirality remains unknown. Here, we characterize the sequence specificity of the central core of amyloid-β 42 and design derivatives which enable chirality inversion at biologically relevant temperatures. We further find that C-terminal modifications can tune the energy barrier of a left-to-right chiral inversion. Leveraging this design principle, we demonstrate how temperature-triggered chiral inversion of peptides hosting therapeutic payloads modulates the dosed release of an anticancer drug. These results suggest a generalizable approach for fine-tuning supramolecular chirality that can be applied in developing treatments to regulate amyloid morphology in neurodegeneration as well as in other disease states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.