Evidence map›Paper›PMID 38278606›Full record

ReviewSurgical pathology clinics2024

Sarcomas with EWSR1::Non-ETS Fusion (EWSR1::NFATC2 and EWSR1::PATZ1).

Isidro Machado, Antonio Llombart-Bosch, Gregory W Charville, Samuel Navarro, María Purificación Domínguez Franjo, Julia A Bridge, Konstantinos Linos

Open access · greenAbstract readReview
In one paragraph

Review in Surgical pathology clinics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Isidro MachadoPathology Department, Instituto Valenciano de Oncología, Valencia, Spain; Patologika Laboratory, Hospital Quiron-Salud, Valencia, Spain; Pathology Department, University of Valencia, Valencia, Spain. Electronic address: Isidro.machado@uv.es.
Antonio Llombart-BoschPathology Department, university of Valencia, Spain and Cancer CIBER (CIBERONC), Madrid, Spain.
Gregory W CharvilleDepartment of Pathology, Stanford University, Stanford, CA, USA.
Samuel NavarroPathology Department, university of Valencia, Spain and Cancer CIBER (CIBERONC), Madrid, Spain.
María Purificación Domínguez FranjoPathology Department, Hospital Ruber Internacional, Madrid, Spain.
Julia A BridgeDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Molecular Pathology, ProPath, Dallas, TX, USA.
Konstantinos LinosDepartment of Pathology & Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: linosk@mskcc.org.
Centro de Investigación Biomédica en Red de Cáncer · ESHospital Ruber Internacional · ESMemorial Sloan Kettering Cancer Center · USPropath Services (United States) · USStanford University · USUniversitat de València · ES

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

The wide application of increasingly advanced molecular studies in routine clinical practice has allowed a detailed, albeit still incomplete, genetic subclassification of undifferentiated round cell sarcomas. The WHO classification continues to include provisional molecular entities, whose clinicopathologic features are in the early stages of evolution. This review focuses on the clinicopathologic, molecular, and prognostic features of undifferentiated round cell sarcomas with EWSR1/FUS::NFATC2 or EWSR1::PATZ1 fusions. Classic histopathologic findings, uncommon variations, and diagnostic pitfalls are addressed, along with the utility of recently developed immunohistochemical and molecular markers.

Indexed as

SarcomaBiomarkers, TumorHumansKruppel-Like Transcription FactorsNFATC Transcription FactorsPrognosisRepressor ProteinsRNA-Binding Protein EWSTranscription FactorsBiomarkers, TumorEWSR1 protein, humanKruppel-Like Transcription FactorsNFATC2 protein, humanNFATC Transcription FactorsPATZ1 protein, humanRepressor ProteinsRNA-Binding Protein EWSTranscription FactorsEWSR1::NFATC2 sarcomaEWSR1::non-ETS sarcomaEWSR1::PATZ1 sarcomaUndifferentiated round cell sarcoma

Identifiers

PMID38278606
PMCPMC12439224
OpenAlexW4385618093

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.