Evidence map›Paper›PMID 38278174›Full record

ArticleOphthalmology. Retina2024

Local and Global Associations of Reticular Pseudodrusen in Age-Related Macular Degeneration.

Cameron Duic, Souvick Mukherjee, Kristina Pfau, Alisa Thavikulwat, Amitha Domalpally, Tiarnan D L Keenan, Emily Chew, Catherine Cukras

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology. Retina, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Cameron DuicDivision of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Souvick MukherjeeDivision of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Kristina PfauDepartment of Ophthalmology, University Hospital Bonn, Bonn, Germany; Department of Ophthalmology, University Hospital Basel, Basel, Switzerland.
Alisa ThavikulwatDivision of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Amitha DomalpallyDepartment of Ophthalmology, University of Wisconsin, Madison, Wisconsin.
Tiarnan D L KeenanDivision of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Emily ChewDivision of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Catherine CukrasDivision of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland. Electronic address: cukrasc@hotmail.com.
National Institutes of Health · USUniversity Hospital Bonn · DEUniversity of Wisconsin–Madison · US

Funding

Intramural NIH HHS Z99 EY999999
6 · The paper itself

Abstract

purposeTo investigate the spatial distribution of reticular pseudodrusen (RPD) in eyes with age-related macular degeneration (AMD) and their correlation with functional measures, retinal thickness, and changes over time.

designLongitudinal, cohort study.

participantsThirty-five participants with RPD and spectrum of AMD severity (including no AMD).

methodsMultimodal imaging was graded by a reading center, including evaluation of color fundus imaging to assess AMD severity scores. Reticular pseudodrusen presence on OCT volumes was confirmed on en face imaging and the RPD extent was contoured on infrared images. One study eye per participant underwent rod-mediated dark adaptation, measuring rod intercept time (RIT) at 5° and, if needed, 12° superior to the fovea.

main outcome measuresThe primary outcome was RIT and OCT thickness measures which were correlated with RPD area.

resultsA total of 51 eyes had ≥ 1 visit with RPD detected (mean follow-up, 2.19 ± 2.04 years; range, 0-5 years), totaling 169 eye-based visits with RPD. Of the 51 eyes with RPD, 5 (9.8%) developed geographic atrophy and 17 (33.3%) progressed to neovascular AMD. Larger RPD areas were detected more frequently in AMD severity scores 6-7. Reticular pseudodrusen area within an eye generally increased over time. The lesion distribution showed a predilection for the superior retina, especially the outer superior subfield of the ETDRS grid, with the central subfield having least involvement. Reticular pseudodrusen area was inversely correlated with central subfield thickness and positively correlated with RIT at 5° (P = 0.001; r

conclusionsIn AMD, RPD involve predominantly the superior retina but can involve all ETDRS subfields and evolve over time. Eyes with RPD exhibit structural and functional impairments that can be measured beyond the boundaries of the RPD lesions, suggesting changes associated with RPD are associated with both local changes and a more widespread process. FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Fluorescein AngiographyFundus OculiRetinal DrusenTomography, Optical CoherenceAgedAged, 80 and overDark AdaptationDisease ProgressionFemaleFollow-Up StudiesHumansMacular DegenerationMaleMiddle AgedMultimodal ImagingRetinaAge-related macular degenerationReticular pseudodrusenRod intercept timeRod-mediated dark adaptation

Identifiers

PMID38278174
PMCPMC13508067
OpenAlexW4391179796

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.