ArticleNeuron2024
Glutamate inputs send prediction error of reward, but not negative value of aversive stimuli, to dopamine neurons.
Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Acute fentanyl induces opposing directions of changes in tonic and phasic dopamine release patterns and impairs Pavlovian task performance.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Dopamine dynamics as a regulatory mechanism for shifting between defensive and reward-seeking behaviors.Communications biology · 2026Article
- Dopamine in the ventral and tail of striatum supports global and local evaluation in reward-threat conflict.bioRxiv : the preprint server for biology · 2026Article
- The superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning.Nature communications · 2026Article
- Phasic dopamine drives conditioned responding beyond its role in learning.bioRxiv : the preprint server for biology · 2026Article
- Glutamate indicators with increased sensitivity and tailored deactivation rates.Nature methods · 2026Article
- The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events.Science advances · 2026Article
- Dopamine as a teaching signal: understanding its role in shaping individual behavior.Signal transduction and targeted therapy · 2025Article
- Flexible updating of reward and punishment contingencies by VTA GABA neurons.Current biology : CB · 2025Article
- Fluorescence detection of dopamine signaling to the primate striatum in relation to stimulus-reward associations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms.eLife · 2025Article
- How Dopamine Enables Learning from Aversion.Current opinion in behavioral sciences · 2025Article
- Fiber photometry in neuroscience research: principles, applications, and future directions.Pharmacological reports : PR · 2024Review
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Abstract
Midbrain dopamine neurons are thought to signal reward prediction errors (RPEs), but the mechanisms underlying RPE computation, particularly the contributions of different neurotransmitters, remain poorly understood. Here, we used a genetically encoded glutamate sensor to examine the pattern of glutamate inputs to dopamine neurons in mice. We found that glutamate inputs exhibit virtually all of the characteristics of RPE rather than conveying a specific component of RPE computation, such as reward or expectation. Notably, whereas glutamate inputs were transiently inhibited by reward omission, they were excited by aversive stimuli. Opioid analgesics altered dopamine negative responses to aversive stimuli into more positive responses, whereas excitatory responses of glutamate inputs remained unchanged. Our findings uncover previously unknown synaptic mechanisms underlying RPE computations; dopamine responses are shaped by both synergistic and competitive interactions between glutamatergic and GABAergic inputs to dopamine neurons depending on valences, with competitive interactions playing a role in responses to aversive stimuli.
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