Evidence map›Paper›PMID 38278093›Full record

ArticleJournal of the neurological sciences2024

Avocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study.

Stephen A Goutman, Jonathan Boss, Dae Gyu Jang, Caroline Piecuch, Hasan Farid, Madeleine Batra, Bhramar Mukherjee, Eva L Feldman, Stuart A Batterman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the neurological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Life Course Exposure to Cyanobacteria and Amyotrophic Lateral Sclerosis Survival.International journal of environmental research and public health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Stephen A GoutmanDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States of America; NeuroNetwork for Emerging Therapies, University of Michigan, Ann Arbor, MI, United States of America. Electronic address: sgoutman@med.umich.edu.
Jonathan BossDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, United States of America. Electronic address: bossjona@umich.edu.
Dae Gyu JangDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States of America; NeuroNetwork for Emerging Therapies, University of Michigan, Ann Arbor, MI, United States of America. Electronic address: dajang@med.umich.edu.
Caroline PiecuchDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States of America. Electronic address: carolinp@med.umich.edu.
Hasan FaridDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States of America. Electronic address: hafarid@med.umich.edu.
Madeleine BatraDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States of America. Electronic address: mabatra@med.umich.edu.
Bhramar MukherjeeDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, United States of America. Electronic address: bhramar@umich.edu.
Eva L FeldmanDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States of America; NeuroNetwork for Emerging Therapies, University of Michigan, Ann Arbor, MI, United States of America. Electronic address: efeldman@med.umich.edu.
Stuart A BattermanDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, United States of America. Electronic address: stuartb@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STUART A BATTERMAN · 2011 to 2026
$21.3M
Mapping the ALS Exposome to Gain New Insights into Disease Risk and PathogenesisR01ES030049 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BATTERMAN, STUART A, FELDMAN, EVA LUCILLE · 2020 to 2024
$3.5M
Developing novel strategies for personalized treatment and prevention of ALS: Leveraging the global exposome, genome, epigenome, metabolome, and inflammasome with data science in a case/control cohortR01NS127188 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BATTERMAN, STUART A, FELDMAN, EVA LUCILLE · 2021 to 2024
$3.4M
RFA-TS-23-001: Establishing the Cohort for Occupational Risk and Prevention Studies for Amyotrophic Lateral Sclerosis (ALS CORPS)R01TS000344 · TS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FELDMAN, EVA LUCILLE, GOUTMAN, STEPHEN · 2023 to 2025
$1.5M
Linking long-term air pollution exposure with inflammation, ALS risk, and disease progressionR01TS000327 · TS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FELDMAN, EVA LUCILLE, GOUTMAN, STEPHEN · 2021 to 2023
$1.4M
Impact of Geospatial Factors and Environmental Pollutants on Amyotrophic Lateral Sclerosis in the State of MichiganK23ES027221 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GOUTMAN, STEPHEN · 2017 to 2021
$1.0M
ACL HHS R01TS000344ATSDR CDC HHS R01 TS000327ATSDR CDC HHS R01 TS000344NCATS NIH HHS UL1 TR002240NIEHS NIH HHS K23 ES027221NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES030049NINDS NIH HHS R01 NS127188
6 · The paper itself

Abstract

introductionEnvironmental exposures strongly influence ALS risk and identification is needed to reduce ALS burden. Participation in hobbies and exercise may alter ALS risk and phenotype, warranting an assessment to understand their contribution to the ALS exposome.

methodsParticipants with ALS and healthy controls were recruited from University of Michigan and self-completed a survey to ascertain hobbies, exercise, and avocational exposures. Exposure variables were associated with ALS risk, survival, onset segment, and onset age.

resultsALS (n = 400) and control (n = 287) participants self-reported avocational activities. Cases were slightly older (median age 63.0 vs. 61.1 years, p = 0.019) and had a lower educational attainment (p < 0.001) compared to controls; otherwise, demographics were well balanced. Risks associating with ALS after multiple comparison correction included golfing (odds ratio (OR) 3.48, p DISCUSSION: The identified exposures in this study may represent important modifiable ALS factors that influence ALS phenotype. Thus, exposures related to hobbies and exercise should be captured in studies examining the ALS exposome.

Indexed as

Amyotrophic Lateral SclerosisEnvironmental ExposureCase-Control StudiesHumansMichiganMiddle AgedPhenotypeRisk FactorsALSALS exposuresAvocational risk factorsExerciseFirearmsGolfGunsHobby risk factorsHuntingShootingSportsSwimmingWeightliftingWoodwork

Identifiers

PMID38278093
PMCPMC11060628
OpenAlexW4391115767

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.