Evidence map›Paper›PMID 38278000›Full record

ArticlePlacenta2024

Synthesis of phospholipids in human placenta.

Theresa L Powell, Veronique Ferchaud-Roucher, Lana Madi, Charis Uhlson, Karin Zemski-Berry, Avery C Kramer, Kathryn Erickson, Claire Palmer, Stephanie S Chassen, Marisol Castillo-Castrejon

Open access · greenAbstract read
In one paragraph

Article in Placenta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Theresa L PowellDepartments of Pediatrics, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, CO 80045, USA; Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, CO 80045, USA. Electronic address: Theresa.Powell@cuanschutz.edu.
Veronique Ferchaud-RoucherUniversity of Nantes-INRAE UMR 1280 PhAN, CHU Nantes, CRNH Ouest CHU Hotel Dieu, 1 place Alexis Ricordeau, 1er etage aile nord HNB, 44093, Nantes Cedex 1, France. Electronic address: Veronique.Ferchaud-Roucher@univ-nantes.fr.
Lana MadiObstetrics and Gynecology, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, CO 80045, USA. Electronic address: Lana.Madi@cuanschutz.edu.
Charis UhlsonDepartments of Pediatrics, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, CO 80045, USA. Electronic address: Charis.Uhlson@cuanschutz.edu.
Karin Zemski-BerryMedicine, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, CO 80045, USA. Electronic address: Karin.Zemskiberry@cuanschutz.edu.
Avery C KramerObstetrics and Gynecology, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, CO 80045, USA. Electronic address: Avery.Kramer@CUAnschutz.edu.
Kathryn EricksonDepartments of Pediatrics, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, CO 80045, USA. Electronic address: Kathryn.Erickson@CUAnschutz.edu.
Claire PalmerDepartments of Pediatrics, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, CO 80045, USA. Electronic address: palmerclr@me.com.
Stephanie S ChassenDepartments of Pediatrics, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, CO 80045, USA. Electronic address: Stephanie.Chassen@cuanschutz.edu.
Marisol Castillo-CastrejonDepartment of Pathology, University of Oklahoma Health Sciences Center, 975 NE 10th St., Stanton L Young Biomedical Research Center Room 458, Oklahoma City, OK, 73104, USA. Electronic address: Marisol-Castillocastrejon@ouhsc.edu.
University of Colorado Anschutz Medical Campus · USInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · FRUniversity of Oklahoma Health Sciences Center · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Novel Roles for Phospholipids in Regulating Placental Function and in the Delivery of DHA to the Fetal Brain.R01HD104644 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Theresa L Powell · 2022 to 2026
$2.5M
NCATS NIH HHS UL1 TR001082NICHD NIH HHS R01 HD104644
6 · The paper itself

Abstract

introductionPlacental phospholipid synthesis is critical for the expansion of the placental exchange surface area and for production of signaling molecules. Despite their importance, it is not yet established which enzymes involved in the de novo synthesis and remodeling of placental phospholipids are expressed and active in the human placenta.

methodsWe identified phospholipid synthesis enzymes by immunoblotting in placental homogenates and immunofluorescence in placenta tissue sections. Primary human trophoblast (PHT) cells from term healthy placentas (n = 10) were cultured and exposed to

resultsAcyl transferase and phospholipase enzymes were detected in human placenta homogenate and primarily expressed in the syncytiotrophoblast. Three representative

conclusionsPhospholipid synthesis and remodeling enzymes are present in the syncytiotrophoblast.

Indexed as

PhospholipidsPlacentaFatty AcidsFemaleHumansLysophosphatidylcholinesPhosphatidylcholinesPregnancyFatty AcidsLysophosphatidylcholinesPhosphatidylcholinesPhospholipidsFetal developmentLysophospholipidsMaternal-fetal exchangePhosphatidic acidPregnancyTrophoblast

Identifiers

PMID38278000
PMCPMC10923060
OpenAlexW4391062572

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.