Evidence map›Paper›PMID 38277448›Full record

ArticleScience advances2024

Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome.

Abhimanu Pandey, Cheng Shen, Shouya Feng, Daniel Enosi Tuipulotu, Chinh Ngo, Cheng Liu, Melan Kurera, Anukriti Mathur, Shweta Venkataraman, Jing Zhang and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  2. Review
  3. In Vitro Antiviral Activity of Red Algae Extracts fromTropical medicine and infectious disease · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Abhimanu PandeyDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.ORCID 0000-0002-2367-3422
Cheng ShenDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.ORCID 0000-0002-6098-1205
Shouya FengDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Daniel Enosi TuipulotuDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.ORCID 0000-0002-6442-4633
Chinh NgoDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Cheng LiuConjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Australia.
Melan KureraDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.ORCID 0009-0004-6901-8505
Anukriti MathurDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Shweta VenkataramanDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Jing ZhangDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Dipti TalaulikarDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.ORCID 0000-0001-6766-8345
Renhua SongEpigenetics and RNA Biology Program Centenary Institute, The University of Sydney, Camperdown 2050, Australia.ORCID 0000-0002-8228-7281
Justin J-L WongEpigenetics and RNA Biology Program Centenary Institute, The University of Sydney, Camperdown 2050, Australia.ORCID 0000-0002-7038-5079
Narci TeohGastroenterology and Hepatology Unit, The Australian National University Medical School at The Canberra Hospital, The Australian National University, Canberra, Australia.
Nadeem O KaakoushSchool of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0003-4017-1077
Si Ming ManDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.ORCID 0000-0002-5079-2857
Australian National University · AUThe University of Sydney · AUMater Health Services · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The innate immune response contributes to the development or attenuation of acute and chronic diseases, including cancer. Microbial DNA and mislocalized DNA from damaged host cells can activate different host responses that shape disease outcomes. Here, we show that mice and humans lacking a single allele of the DNA repair protein Ku70 had increased susceptibility to the development of intestinal cancer. Mechanistically, Ku70 translocates from the nucleus into the cytoplasm where it binds to cytosolic DNA and interacts with the GTPase Ras and the kinase Raf, forming a tripartite protein complex and docking at Rab5

Indexed as

NeoplasmsSignal TransductionAnimalsCell ProliferationDNAHumansKu AutoantigenMAP Kinase Signaling SystemMiceDNAKu AutoantigenXrcc6 protein, humanXrcc6 protein, mouse

Identifiers

PMID38277448
PMCPMC10816715
OpenAlexW4391249187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.