Evidence map›Paper›PMID 38277302›Full record

ArticleJournal of Parkinson's disease2024

Working Memory Training Responsiveness in Parkinson's Disease Is Not Determined by Cortical Thickness or White Matter Lesions.

Kathrin Giehl, Hendrik Theis, Anja Ophey, Jochen Hammes, Paul Reker, Carsten Eggers, Gereon R Fink, Elke Kalbe, Thilo van Eimeren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. The cerebellum beyond motor control: cognitive dysfunction in spinocerebellar ataxias.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kathrin GiehlDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Multimodal Neuroimaging Group, Cologne, Germany.
Hendrik TheisDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Multimodal Neuroimaging Group, Cologne, Germany.
Anja OpheyDepartment of Medical Psychology, Faculty of Medicine and University Hospital Cologne, Neuropsychology and Gender Studies and Center for Neuropsychological Diagnostics and Intervention (CeNDI), University of Cologne, Cologne, Germany.
Jochen HammesDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Multimodal Neuroimaging Group, Cologne, Germany.
Paul RekerDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Carsten EggersDepartment of Neurology, Knappschaftskrankenhaus Bottrop, Bottrop, Germany.
Gereon R FinkDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Elke KalbeDepartment of Medical Psychology, Faculty of Medicine and University Hospital Cologne, Neuropsychology and Gender Studies and Center for Neuropsychological Diagnostics and Intervention (CeNDI), University of Cologne, Cologne, Germany.
Thilo van EimerenDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Multimodal Neuroimaging Group, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with Parkinson's disease are highly vulnerable for cognitive decline. Thus, early intervention by means of working memory training (WMT) may be effective for the preservation of cognition. However, the influence of structural brain properties, i.e., cortical thickness and volume of white matter lesions on training responsiveness have not been studied. Here, behavioral and neuroimaging data of 46 patients with Parkinson's disease, 21 of whom engaged in home-based, computerized adaptive WMT, was analyzed. While cortical thickness and white matter lesions volume were associated with cognitive performance at baseline, these structural brain properties do not seem to determine WMT responsiveness.

Indexed as

Cognitive DysfunctionParkinson DiseaseWhite MatterBrainCognitive TrainingHumansMagnetic Resonance ImagingNeuropsychological Testscognitioncortical thicknessMRIParkinson’s diseasewhite matter lesionWorking memory training

Identifiers

PMID38277302
PMCPMC10977422

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.