Evidence map›Paper›PMID 38277217›Full record

ArticleAging2024

(-)-Epicatechin protects against myocardial ischemia/reperfusion injury via autophagy-dependent ferroptosis.

Kong Junhong, Tsai Yun, Shui Guangxing, Ding Yuhan, Xiang Qian, Zhang Haowen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kong JunhongNanjing University of Chinese Medicine Affiliated Changzhou Hospital, Changzhou 213000, Jiangsu, China.
Tsai YunNanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China.
Shui GuangxingDepartment of Nephrology, Shanghai Jiading Hospital of Traditional Chinese Medicine, Shanghai 201899, China.
Ding YuhanNanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China.
Xiang QianNanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China.
Zhang HaowenNanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China.
Nanjing University of Chinese Medicine · CNShanghai Traditional Chinese Medicine Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aim(-)-Epicatechin (EPI) has physiological activities such as antioxidant, anti-inflammatory and immune enhancement. In this study, we elucidated the protective effects of EPI in myocardial ischemia/reperfusion injury (MI/RI) and its mechanisms.

methodsAn

resultsEPI reduced abnormal electrocardiogram waveform and infarct size caused by MI/RI in rats. The increasing trend of levels of reactive oxygen species (ROS) and Fe

conclusionsEPI can reduce the level of oxidative stress by promoting USP14 to reduce autophagy, thus inhibiting autophagy dependent ferroptosis and reducing oxidative stress, and has a protective effect on myocardial infarction/myocardial infarction.

Indexed as

CatechinFerroptosisMyocardial InfarctionMyocardial Reperfusion InjuryAnimalsAutophagyRatsRats, Sprague-DawleyReactive Oxygen SpeciesCatechinReactive Oxygen Speciesautophagy(-)-Epicatechinferroptosismyocardial ischemia reperfusionROS

Identifiers

PMID38277217
PMCPMC10911377
OpenAlexW4391217742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.