ArticleObesity surgery2024
Comparison of Histological Skin Changes After Massive Weight Loss in Post-bariatric and Non-bariatric Patients.
Article in Obesity surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Postmastectomy Breast Reconstruction Following Massive Weight Loss: An Updated Systematic Review and Identification of Research Gaps.Microsurgery · 2026Pooled it
- Article
- Modified Bikini Line Sleeve Gastrectomy (MBLSG): Defining Surgical Landmarks and Clinical Outcomes in a Large-Scale Cohort of 906 Patients.Medicina (Kaunas, Lithuania) · 2026Article
- Aesthetic Considerations for Preventing and Managing GLP-1 Receptor Agonist-Related Facial Aging.The Journal of clinical and aesthetic dermatology · 2026Article
- Implant-based versus autologous mastopexy after massive weight loss: Complications and patient satisfaction.JPRAS open · 2026Article
- Review
- Enhancing Breast Contours After Major Weight Loss: An Observational Study on the Dilemma of Implant Use.Plastic and reconstructive surgery. Global open · 2026Article
- Assessing the Safety and Aesthetic Benefits of Reduced Port Bikini-Line Sleeve Gastrectomy (RBSG): An Initial Report.Obesity surgery · 2025Article
- GLP-1RA and the possible skin aging.Endocrine · 2025Review
- Early Structural Degradation of Dermal Elastic Fibers in Women with Mild Obesity Without Parallel Transcriptional Changes.Journal of clinical medicine · 2025Article
- Surgical Wound Complications in Postbariatric Patients Undergoing Body Contouring Plastic Surgeries: The Challenges of Healing.Obesity surgery · 2025Article
- The impact of weight loss after bariatric surgeries on the patient's body image, quality of life, and self-esteem.Langenbeck's archives of surgery · 2025Article
- Exploring Complication Risks and Innovations in Postweight Loss Recovery of Emerging Anti-obesity Medications.Obesity surgery · 2024Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChanges in the skin structure, including the collagen and elastin content, have been reported with massive weight loss (MWL) following bariatric metabolic surgery (BMS) and have been correlated to a higher risk of complications after body-contouring surgery (BCS). This study aimed at comparing the histological characteristics of the skin of patients having surgical MWL (SMWL) post-BMS to those with non-surgical massive weight loss (NSMWL).
methodsThis prospective study compared the epidermal thickness, and collagen and elastin fibers content in 80 skin biopsies obtained from BCS procedures performed to patients who experienced MWL defined more than 50% of excess weight loss (%EWL) either SMWL (40 biopsies) or NSMWL (40 biopsies). Twenty biopsies in each group were obtained from abdominoplasties and 20 from breast reductions. Epidermal thickness was measured in H&E-stained sections, collagen fibers were assessed using Masson trichrome-stained sections, and elastin fibers were assessed using Modified Verhoeff's stained sections. Image analysis software was used to calculate the fractions of collagen and elastin fibers.
resultsThis study included 77 patients, 38 SMWL patients, and 39 NSMWL patients. The SMWL group had a significantly higher age (p < 0.001), a longer time interval from intervention (p < 0.001), higher initial weight (p < 0.001), higher initial BMI (p < 0.001), lower current weight (p = 0.005), lower current BMI (p < 0.001), and significantly higher %EWL than NSMWL group (p < 0.001). No significant differences were detected between the two groups regarding complications after abdominoplasty (p = 1.000). The elastic fibers content in the dermis was significantly higher in the abdominal region of the NSMWL group than SMWL (p = 0.029). All other parameters showed non-significant differences between NSMWL and SMWL in the skin of abdomen and breast.
conclusionThe SMWL group had a significant reduction in elastic fiber content in the skin of the abdomen compared to the NSMWL group. The collagen content was equally reduced in both groups with non-significant differences in both breast and abdomen regions in both groups.
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