Evidence map›Paper›PMID 38276895›Full record

ArticleJournal of chemical information and modeling2024

Investigating Polypharmacology through Targeting Known Human Neutrophil Elastase Inhibitors to Proteinase 3.

Parveen Gartan, Fahimeh Khorsand, Pushpak Mizar, Juha Ilmari Vahokovski, Luis F Cervantes, Bengt Erik Haug, Ruth Brenk, Charles L Brooks, Nathalie Reuter

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of chemical information and modeling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Core Flipping in Lead Optimization: Rank Ordering Using λ-Dynamics.Journal of chemical information and modeling · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Parveen GartanDepartment of Chemistry, University of Bergen, Bergen 5020, Norway.
Fahimeh KhorsandDepartment of Biomedicine, University of Bergen, Bergen 5020, Norway.
Pushpak MizarDepartment of Chemistry, University of Bergen, Bergen 5020, Norway.
Juha Ilmari VahokovskiCore Facility for Biophysics, Structural Biology, and Screening, Department of Biomedicine, University of Bergen, Bergen 5020, Norway.
Luis F CervantesDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
Bengt Erik HaugDepartment of Chemistry, University of Bergen, Bergen 5020, Norway.ORCID 0000-0003-3014-9538
Ruth BrenkDepartment of Biomedicine, University of Bergen, Bergen 5020, Norway.ORCID 0000-0002-6204-5488
Charles L BrooksDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-8149-5417
Nathalie ReuterDepartment of Chemistry, University of Bergen, Bergen 5020, Norway.ORCID 0000-0002-3649-7675
University of Bergen · NOUniversity of Michigan · US

Funding

Theory and Modeling of Biomolecules and their Interactions - Equipment SupplementR35GM130587 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHARLES L BROOKS · 2019 to 2026
$6.9M
NIGMS NIH HHS R35 GM130587
6 · The paper itself

Abstract

Using a combination of multisite λ-dynamics (MSλD) together with

Indexed as

PolypharmacologyHumansMyeloblastinProteinase Inhibitory Proteins, SecretoryMyeloblastinProteinase Inhibitory Proteins, Secretory

Identifiers

PMID38276895
PMCPMC10865350
OpenAlexW4391253592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.