ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Harmonizing florbetapir and PiB PET measurements of cortical Aβ plaque burden using multiple regions-of-interest and machine learning techniques: An alternative to the Centiloid approach.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease.NPJ digital medicine · 2026Article
- Molecular design of MRI probes for targeting amyloid-β species: fromTheranostics · 2026Review
- Enhancing Amyloid PET Quantification: MRI-Guided Super-Resolution Using Latent Diffusion Models.Life (Basel, Switzerland) · 2024Article
- Evaluation of ComBat Harmonization for Reducing Across-Tracer Differences in Regional Amyloid PET Analyses.Human brain mapping · 2024Article
- Harmonizing florbetapir and PiB PET measurements of cortical Aβ plaque burden using multiple regions-of-interest and machine learning techniques: An alternative to the Centiloid approach.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Accounting for white matter uptake improves between tracer agreement in amyloid PET.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
8 authors.
Funding
Abstract
introductionMachine learning (ML) can optimize amyloid (Aβ) comparability among positron emission tomography (PET) radiotracers. Using multi-regional florbetapir (FBP) measures and ML, we report better Pittsburgh compound-B (PiB)/FBP harmonization of mean-cortical Aβ (mcAβ) than Centiloid.
methodsPiB-FBP pairs from 92 subjects in www.oasis-brains.org and 46 in www.gaain.org/centiloid-project were used as the training/testing sets. FreeSurfer-extracted FBP multi-regional Aβ and actual PiB mcAβ in the training set were used to train ML models generating synthetic PiB mcAβ. The correlation coefficient (R) between the synthetic/actual PiB mcAβ in the testing set was assessed.
resultsIn the testing set, the synthetic/actual PiB mcAβ correlation R = 0.985 (R DISCUSSION: ML improved mcAβ comparability. Additional studies are needed for the generalizability to other amyloid tracers, and to tau PET. Highlights Centiloid is a calibration of the amyloid scale, not harmonization. Centiloid unifies the amyloid scale without improving inter-tracer association (R
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