Evidence map›Paper›PMID 38276634›Full record

ArticleTropical medicine and infectious disease2023

Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly Isoniazid-Rifapentine Regimen in Bangladesh: A Community-Based Implementation Study.

Md Toufiq Rahman, Farzana Hossain, Rupali Sisir Banu, Md Shamiul Islam, Shamsher Alam, Abu Jamil Faisel, Hamid Salim, Oscar Cordon, Pedro Suarez, Hamidah Hussain and 1 more

Open access · goldAbstract read
In one paragraph

Article in Tropical medicine and infectious disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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  5. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Md Toufiq RahmanInteractive Research and Development, Bangladesh (IRD Bangladesh), Dhaka 1212, Bangladesh.ORCID 0000-0003-3230-7990
Farzana HossainInteractive Research and Development, Bangladesh (IRD Bangladesh), Dhaka 1212, Bangladesh.
Rupali Sisir BanuNational Tuberculosis Control Program, Directorate General of Health Services, Ministry of Health and Family Welfare, Dhaka 1212, Bangladesh.
Md Shamiul IslamDirectorate General of Health Services, Ministry of Health and Family Welfare, Dhaka 1212, Bangladesh.
Shamsher AlamInteractive Research and Development, Bangladesh (IRD Bangladesh), Dhaka 1212, Bangladesh.
Abu Jamil FaiselInteractive Research and Development, Bangladesh (IRD Bangladesh), Dhaka 1212, Bangladesh.
Hamid SalimNational Tuberculosis Control Program, Directorate General of Health Services, Ministry of Health and Family Welfare, Dhaka 1212, Bangladesh.
Oscar CordonChallenge TB Project, Management Sciences for Health, Dhaka 1212, Bangladesh.
Pedro SuarezManagement Sciences for Health, Arlington, TX 22203, USA.
Hamidah HussainIRD Global, Singapore 048581, Singapore.ORCID 0000-0002-6585-9815
Tapash RoyInteractive Research and Development, Bangladesh (IRD Bangladesh), Dhaka 1212, Bangladesh.ORCID 0000-0002-8133-2634
Directorate General of Health Services · BDActionAid · USGlobal Antibiotic Research & Development Partnership · CHManagement Sciences for Health · US

Funding

United States Agency for International Development AID-OAA-A-14-00029
6 · The paper itself

Abstract

backgroundThe United Nations high-level meeting (UNHLM) pledged to enroll 30 million in tuberculosis preventive treatment (TPT) by 2022, necessitating TPT expansion to all at tuberculosis (TB) risk. We assessed the uptake and completion of a 12-dose, weekly isoniazid-rifapentine (3HP) TPT regimen.

methodsBetween February 2018 and March 2019 in Dhaka, community-based TPT using 3HP targeted household contacts of 883 confirmed drug-sensitive pulmonary TB patients. Adhering to World Health Organization guidelines, contacts underwent active TB screening before TPT initiation.

resultsOf 3193 contacts who were advised health facility visits for screening, 67% (

conclusionsThe 3HP regimen, with its short duration, self-administered option, and minimal side effects, achieved satisfactory completion rates. A community-focused TPT approach is feasible, scalable nationally, and aligns with UNHLM targets.

Indexed as

3HPBangladeshEnd TBTB preventive treatmentTPTUNHLM

Identifiers

PMID38276634
PMCPMC10820244
OpenAlexW4390034683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.