An Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) Method for Qualifying DAPB in Rat Plasma and Application to Pharmacokinetic Studies.
Bei Qin, Yunmei Chen, Kuan Yang, Rong Wang, Lili Yu, Nana Wang, Shaojing Liu
Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
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1 · What the graph read from it
What it found
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5 · Who and what money
Authors and funding
7 authors.
Bei QinXi'an Key Laboratory for Research and Development of Innovative Multi-Target Antihypertensive Drugs, Xi'an Innovative Antihypertensive Drugs International Science and Technology Cooperation Base, Xi'an Medical University, Xi'an 710021, China.ORCID 0000-0003-0015-7676
Yunmei ChenXi'an Key Laboratory for Research and Development of Innovative Multi-Target Antihypertensive Drugs, Xi'an Innovative Antihypertensive Drugs International Science and Technology Cooperation Base, Xi'an Medical University, Xi'an 710021, China.
Kuan YangXi'an Key Laboratory for Research and Development of Innovative Multi-Target Antihypertensive Drugs, Xi'an Innovative Antihypertensive Drugs International Science and Technology Cooperation Base, Xi'an Medical University, Xi'an 710021, China.ORCID 0000-0003-4834-8084
Rong WangXi'an Key Laboratory for Research and Development of Innovative Multi-Target Antihypertensive Drugs, Xi'an Innovative Antihypertensive Drugs International Science and Technology Cooperation Base, Xi'an Medical University, Xi'an 710021, China.
Lili YuXi'an Key Laboratory for Research and Development of Innovative Multi-Target Antihypertensive Drugs, Xi'an Innovative Antihypertensive Drugs International Science and Technology Cooperation Base, Xi'an Medical University, Xi'an 710021, China.
Nana WangXi'an Key Laboratory for Research and Development of Innovative Multi-Target Antihypertensive Drugs, Xi'an Innovative Antihypertensive Drugs International Science and Technology Cooperation Base, Xi'an Medical University, Xi'an 710021, China.
Shaojing LiuXi'an Key Laboratory for Research and Development of Innovative Multi-Target Antihypertensive Drugs, Xi'an Innovative Antihypertensive Drugs International Science and Technology Cooperation Base, Xi'an Medical University, Xi'an 710021, China.
Funding
Research start-up fund of Xi'an Medical University 2021DOC17the Key Research and Development Program of Shaanxi No. 2021ZDLSF03-05the Scientific and Technological Innovation Team project of Xi'an Medical University NO. 2021TD03, 2021TD07the Scientific Research Program Funded by Shaanxi Provincial Education Department 23JK0651,23JP155, 23JC060the Youth Innovation Team Construction Project of Shaanxi Universities 2022-85
6 · The paper itself
Abstract
DAPB, a new molecule including danshensu, borneol, and a mother nucleus of ACEI (Angiotensin-converting enzyme inhibitors), is being developed as an antihypertensive candidate compound. A rapid, accurate, and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was established and validated for the determination of DAPB in rat plasma. Chromatographic separation was performed on an Agilent SB-C18 column after protein precipitation by acetonitrile with a mobile phase consisting of acetonitrile and deionized water with 0.02% formic acid and 5 mM NH
Indexed as
Liquid Chromatography-Mass SpectrometryTandem Mass SpectrometryAcetonitrilesAnimalsChromatography, High Pressure LiquidChromatography, LiquidRatsReproducibility of ResultsAcetonitrilespharmacokinetic studyUPLC–MS/MS
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
An Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) Method for Qualifying DAPB in Rat Plasma and Application to Pharmacokinetic Studies. · full record | OpenQuestion