Evidence map›Paper›PMID 38276569›Full record

ArticleMolecules (Basel, Switzerland)2024

Study of pH and Thermodynamic Parameters via Circular Dichroism Spectroscopy of a Recombinant Human Lactoferrin.

Beatriz L Álvarez-Mayorga, Sergio Romero-Gómez, Jorge L Rosado, Janet Ocampo-Hernández, J Gómez-Guzmán, Luis Ortiz-Frade

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Beatriz L Álvarez-MayorgaFacultad de Química, Universidad Autónoma de Querétaro, Queretaro 76010, Mexico.ORCID 0000-0002-9520-2187
Sergio Romero-GómezFacultad de Química, Universidad Autónoma de Querétaro, Queretaro 76010, Mexico.ORCID 0000-0002-0232-8275
Jorge L RosadoDepartamento de Nutrición Humana, Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Queretaro 76230, Mexico.ORCID 0000-0002-5999-1078
Janet Ocampo-HernándezDepartamento de Electroquímica, Centro de Investigación y Desarrollo Tecnológico en Electroquímica S.C. Parque Tecnológico Querétaro, Sanfandila, Queretaro 76703, Mexico.ORCID 0000-0003-4367-2301
J Gómez-GuzmánDepartamento de Electroquímica, Centro de Investigación y Desarrollo Tecnológico en Electroquímica S.C. Parque Tecnológico Querétaro, Sanfandila, Queretaro 76703, Mexico.ORCID 0000-0003-3063-703X
Luis Ortiz-FradeDepartamento de Electroquímica, Centro de Investigación y Desarrollo Tecnológico en Electroquímica S.C. Parque Tecnológico Querétaro, Sanfandila, Queretaro 76703, Mexico.ORCID 0000-0001-6523-8018

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The production of human recombinant proteins to be used for therapeutic or nutritional purposes must focus on obtaining a molecule that is as close as possible to the native human protein. This biotechnological tool has been documented in various studies published in recent decades, with lactoferrin being one of those that has generated the most interest, being a promising option for recombinant technology. However, stability studies including thermodynamic parameters have not been reported for recombinant lactoferrin (Lf). The objective of this work was to obtain the human recombinant protein using the yeast

Indexed as

LactoferrinCircular DichroismHumansHydrogen-Ion ConcentrationRecombinant ProteinsTemperatureLactoferrinRecombinant Proteinscircular dichroismhuman lactoferrinKomagataella phaffiiprotein denaturalizationrecombinant proteins

Identifiers

PMID38276569
PMCPMC10818261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.