Evidence map›Paper›PMID 38276193›Full record

ArticleMicroorganisms2024

A Novel Multi-Strain E3 Probiotic Formula Improved the Gastrointestinal Symptoms and Quality of Life in Chinese Psoriasis Patients.

Pui Ling Kella Siu, Chi Tung Choy, Helen Hoi Yin Chan, Ross Ka Kit Leung, Un Kei Chan, Junwei Zhou, Chi Ho Wong, Yuk Wai Lee, Ho Wang Chan, Claudia Jun Yi Lo and 3 more

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Pui Ling Kella SiuMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong Kong, China.
Chi Tung ChoyMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong Kong, China.
Helen Hoi Yin ChanMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong Kong, China.
Ross Ka Kit LeungMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong Kong, China.
Un Kei ChanMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong Kong, China.
Junwei ZhouMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong Kong, China.
Chi Ho WongMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong Kong, China.
Yuk Wai LeeMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong Kong, China.
Ho Wang ChanMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong Kong, China.
Claudia Jun Yi LoMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong Kong, China.
Joseph Chi Ching TsuiMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong Kong, China.
Steven King Fan LooMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong Kong, China.
Stephen Kwok Wing TsuiMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong Kong, China.ORCID 0000-0003-0686-4259
Chinese University of Hong Kong · HK

Funding

Hong Kong Society of Gut Microbiome (HKSGM) N/A
6 · The paper itself

Abstract

Psoriasis is a chronic immune-mediated inflammatory disease affecting the skin and other systems. Gastrointestinal disease was found to be correlated with psoriasis in previous studies and it can significantly affect the quality of life of psoriasis patients. Despite the importance of the gut microbiome in gut and skin health having already been demonstrated in many research studies, the potential effect of probiotics on GI comorbidities in psoriasis patients is unclear. To investigate the effects of probiotics on functional GI comorbidities including irritable bowel syndrome, functional constipation, and functional diarrhea in psoriasis patients, we conducted a targeted 16S rRNA sequencing and comprehensive bioinformatic analysis among southern Chinese patients to compare the gut microbiome profiles of 45 psoriasis patients over an 8-week course of novel oral probiotics. All the participants were stratified into responders and non-responders according to their improvement in GI comorbidities, which were based on their Bristol Stool Form Scale (BSFS) scores after intervention. The Dermatological Life Quality Index (DLQI) score revealed a significant improvement in quality of life within the responder group (DLQI: mean 10.4 at week 0 vs. mean 15.9 at week 8,

Indexed as

gastrointestinal problemsgut microbiomegut–skin axisprobioticspsoriasis

Identifiers

PMID38276193
PMCPMC10820679
OpenAlexW4391027267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.