Evidence map›Paper›PMID 38275969›Full record

ArticleViruses2024

Genomic Expedition: Deciphering Human Adenovirus Strains from the 2023 Outbreak in West Bengal, India: Insights into Viral Evolution and Molecular Epidemiology.

Ananya Chatterjee, Uttaran Bhattacharjee, Rudrak Gupta, Ashis Debnath, Agniva Majumdar, Ritubrita Saha, Mamta Chawla-Sarkar, Alok Kumar Chakrabarti, Shanta Dutta

Abstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ananya ChatterjeeVirus Research and Diagnostic Laboratory, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata 700010, West Bengal, India.ORCID 0000-0003-4777-281X
Uttaran BhattacharjeeDivision of Virology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata 700010, West Bengal, India.ORCID 0000-0002-7433-9256
Rudrak GuptaVirus Research and Diagnostic Laboratory, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata 700010, West Bengal, India.
Ashis DebnathVirus Research and Diagnostic Laboratory, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata 700010, West Bengal, India.
Agniva MajumdarVirus Research and Diagnostic Laboratory, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata 700010, West Bengal, India.ORCID 0000-0001-6111-3971
Ritubrita SahaDivision of Virology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata 700010, West Bengal, India.
Mamta Chawla-SarkarDivision of Virology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata 700010, West Bengal, India.
Alok Kumar ChakrabartiDivision of Virology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata 700010, West Bengal, India.ORCID 0000-0001-7611-909X
Shanta DuttaVirus Research and Diagnostic Laboratory, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata 700010, West Bengal, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the genetic dynamics of circulating Human Adenovirus (HAdV) types is pivotal for effectively managing outbreaks and devising targeted interventions. During the West Bengal outbreak of 2022-2023, an investigation into the genetic characteristics and outbreak potential of circulating HAdV types was conducted. Twenty-four randomly selected samples underwent whole-genome sequencing. Analysis revealed a prevalent recombinant strain, merging type 3 and type 7 of human mastadenovirus B1 (HAd-B1) species, indicating the emergence of recent strains of species B in India. Furthermore, distinctions in VA-RNAs and the E3 region suggested that current circulating strains of human mastadenovirus B1 (HAd-B1) possess the capacity to evade host immunity, endure longer within hosts, and cause severe respiratory infections. This study underscores the significance of evaluating the complete genome sequence of HAdV isolates to glean insights into their outbreak potential and the severity of associated illnesses.

Indexed as

Adenoviruses, HumanAdenovirus Infections, HumanExpeditionsMastadenovirusDisease OutbreaksGenome, ViralGenomicsHumansIndiaMolecular EpidemiologyPhylogenySequence Analysis, DNAgenetic characterisationoutbreakrecombinant strainrespiratory adenoviruswhole genome sequencing

Identifiers

PMID38275969
PMCPMC10820069

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.