Evidence map›Paper›PMID 38275860›Full record

ArticleCancers2024

Multiplex Immunofluorescence Captures Progressive Immune Exhaustion with Advancing Penile Squamous Cell Cancer Stage.

Filip Ionescu, Jonathan Nguyen, Carlos Moran Segura, Mahati Paravathaneni, G Daniel Grass, Peter Johnstone, Niki M Zacharias, Curtis A Pettaway, Xin Lu, Youngchul Kim and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Filip IonescuGenitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.ORCID 0000-0003-3097-8985
Jonathan NguyenPathology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Carlos Moran SeguraPathology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Mahati ParavathaneniGenitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
G Daniel GrassRadiation Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Peter JohnstoneRadiation Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.ORCID 0000-0003-4221-9388
Niki M ZachariasDepartment of Urology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Curtis A PettawayDepartment of Urology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Xin LuDepartment of Biological Sciences, University of Notre Dame, Norte Dame, IN 46556, USA.ORCID 0000-0002-0284-6478
Youngchul KimBiostatistics and Bioinformatics Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Junmin WhitingBiostatistics and Bioinformatics Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Jasreman DhillonPathology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Steven A EschrichBiostatistics and Bioinformatics Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.ORCID 0000-0002-9833-2788
Juskaran ChadhaGenitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Keerthi GullapalliGenitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Gabriel Roman SouzaGenitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.ORCID 0000-0001-5498-2351
Hiroko MiyagiGenitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.ORCID 0000-0002-2071-5463
Brandon J ManleyGenitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.ORCID 0000-0002-7927-1510
Philippe E SpiessGenitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.ORCID 0000-0002-5723-1972
Jad ChahoudGenitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Moffitt Cancer Center · USThe University of Texas MD Anderson Cancer Center · USUniversity of Notre Dame · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Penile squamous cell carcinoma (PSCC) is a rare and deadly malignancy. Therapeutic advances have been stifled by a poor understanding of disease biology. Specifically, the immune microenvironment is an underexplored component in PSCC and the activity of immune checkpoint inhibitors observed in a subset of patients suggests immune escape may play an important role in tumorigenesis. Herein, we explored for the first time the immune microenvironment of 57 men with PSCC and how it varies with the presence of human papillomavirus (HPV) infection and across tumor stages using multiplex immunofluorescence of key immune cell markers. We observed an increase in the density of immune effector cells in node-negative tumors and a progressive rise in inhibitory immune players such as type 2 macrophages and upregulation of the PD-L1 checkpoint in men with N1 and N2-3 disease. There were no differences in immune cell densities with HPV status.

Indexed as

immune microenvironmentmultiplex immunofluorescencepenile squamous cell carcinoma

Identifiers

PMID38275860
PMCPMC10814242
OpenAlexW4390741682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.