Evidence map›Paper›PMID 38275646›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Trihexyphenidyl Alters Its Host's Metabolism, Neurobehavioral Patterns, and Gut Microbiome Feedback Loop-The Modulating Role of

Abdelmounaim Baslam, Hajar Azraida, Rachida Aboufatima, Mohamed Ait-El-Mokhtar, Ilham Dilagui, Samia Boussaa, Abderrahman Chait, Marouane Baslam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Abdelmounaim BaslamLaboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Department of Biology, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech 40000, Morocco.ORCID 0000-0001-9320-3613
Hajar AzraidaLaboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Department of Biology, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech 40000, Morocco.ORCID 0000-0002-2208-8264
Rachida AboufatimaLaboratory of Biological Engineering, Faculty of Sciences and Technology, Sultan Moulay Slimane University, Beni Mellal 23000, Morocco.
Mohamed Ait-El-MokhtarLaboratory of Biochemistry, Environment & Agri-Food URAC 36, Department of Biology, Faculty of Science and Techniques-Mohammedia, Hassan II University of Casablanca, Mohammedia 20000, Morocco.ORCID 0000-0001-8096-9927
Ilham DilaguiLaboratory of Microbiology, University Hospital Mohamed VI, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech 40000, Morocco.
Samia BoussaaHigher Institute of Nursing and Health Techniques, Ministry of Health and Social Protection, Rabat 10000, Morocco.ORCID 0000-0002-5599-1097
Abderrahman ChaitLaboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Department of Biology, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech 40000, Morocco.ORCID 0000-0002-5639-1931
Marouane BaslamLaboratory of Biochemistry, Department of Applied Biological Chemistry, Faculty of Agriculture, University of Niigata, Niigata 950-2181, Japan.ORCID 0000-0003-3598-7565
Cadi Ayyad University · MAInstituts Supérieurs des Professions Infirmières et Techniques de Santé · MAUniversité Hassan II Mohammedia · MAUniversité Sultan Moulay Slimane · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trihexyphenidyl (THP)-a synthetic anticholinergic medication used to manage parkinsonism and extrapyramidal symptoms-has gained significant clinical recognition. However, there is a critical gap in understanding its withdrawal effects. This study investigates the intricate interplay between gut microbiota and oxidative stress during THP withdrawal. Furthermore, it explores the therapeutic potential of

Indexed as

addictionAnacyclus pyrethrumdependencedrug dependencegut–brain axismicrobiomeoxidative stresspellitorysubstance abusetrihexyphenidyl (Artane)

Identifiers

PMID38275646
PMCPMC10812446
OpenAlexW4390112065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.