Evidence map›Paper›PMID 38275389›Full record

ArticleBiomedicines2023

Whole Blood Reactivity to Viral and Bacterial Pathogens after Non-Emergent Cardiac Surgery during the Acute and Convalescence Periods Demonstrates a Distinctive Profile of Cytokines Production Compared to the Preoperative Baseline in Cohort of 108 Patients, Suggesting Immunological Reprogramming during the 28 Days Traditionally Recognized as the Post-Surgical Recovery Period.

Krzysztof Laudanski, Da Liu, Lioudmila Karnatovskaia, Sanghavi Devang, Amal Mathew, Wilson Y Szeto

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Predictive Value of PreoperativeInternational journal of molecular sciences · 2026
    Article
  2. Reframing sepsis research through translational integrative models.Journal of translational internal medicine · 2026
    Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Krzysztof LaudanskiDepartment of Anesthesiology and Perioperative Care, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-7373-0851
Da LiuDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110055, China.
Lioudmila KarnatovskaiaDivision of Pulmonary and Critical Care, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Sanghavi DevangDepartment of Critical Care Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.
Amal MathewSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA.ORCID 0009-0001-5144-4619
Wilson Y SzetoDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mayo Clinic · USChina Medical University · CNDrexel University · USUniversity of Pennsylvania · USWinnMed · US

Funding

UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI VAN DEERLIN, VIVIANNA M · 1991 to 2020
$35.1M
Epigenetic mediated long-term aberrations in myeloid cells after critical illnessK23GM120630 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LAUDANSKI, KRZYSZTOF · 2017 to 2020
$783k
NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG10124NIGMS NIH HHS K23 GM120630
6 · The paper itself

Abstract

The release of danger signals from tissues in response to trauma during cardiac surgery creates conditions to reprogram the immune system to subsequent challenges posed by pathogens in the postoperative period. To demonstrate this, we tested immunoreactivity before surgery as the baseline (t

Indexed as

blood stimulationcardiac surgeryIL-10IL-2IL-6immune systeminflammationM-CSFprofilingreprogrammingTNFα

Identifiers

PMID38275389
PMCPMC10812925
OpenAlexW4390051092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.