Evidence map›Paper›PMID 38275388›Full record

ArticleBiomedicines2023

Induction of Collagenolytic MMP-8 and -9 Tissue Destruction Cascade in Mouth by Head and Neck Cancer Radiotherapy: A Cohort Study.

Ella Brandt, Mutlu Keskin, Ismo T Räisänen, Taina Tervahartiala, Antti Mäkitie, İlknur Harmankaya, Didem Karaçetin, Jaana Hagström, Jaana Rautava, Timo Sorsa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ella BrandtDepartment of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.
Mutlu KeskinOral and Dental Health Department, Altınbaş University, 34147 Istanbul, Turkey.ORCID 0000-0002-1045-3930
Ismo T RäisänenDepartment of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.ORCID 0000-0001-5821-5299
Taina TervahartialaDepartment of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.ORCID 0000-0001-8817-896X
Antti MäkitieDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, P.O. Box 263, 00029 Helsinki, Finland.ORCID 0000-0002-0451-2404
İlknur HarmankayaDepartment of Radiation Oncology, Başakşehir Çam and Sakura City Hospital, 34480 Istanbul, Turkey.
Didem KaraçetinDepartment of Radiation Oncology, Başakşehir Çam and Sakura City Hospital, 34480 Istanbul, Turkey.
Jaana HagströmDepartment of Pathology, Helsinki University Hospital, 00014 Helsinki, Finland.
Jaana RautavaDepartment of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.
Timo SorsaDepartment of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.

Funding

Finnish Association of Women DentistsFinska LäkaresällskapetHospital District of Helsinki and Uusimaa TYH2020337, TYH2022225, Y2519SU010Karolinska Institutetthe Finnish Dental Association Apollonia
6 · The paper itself

Abstract

The effect of head and neck cancer (HNC) radiotherapy (RT) on biomarkers is not known but there is a lot of potential for gaining more precise cancer treatments and less side effects. This cohort study investigated the levels and molecular forms of the matrix metalloproteinase (MMP) -8 and -9, tissue inhibitor of metalloproteinase (TIMP)-1, myeloperoxidase (MPO) and interleukin (IL)-6 in mouth-rinse samples as well as the clinical periodontal status in HNC patients (

Indexed as

aMMP-8biomarkerhead and neck cancermatrix metalloproteinaseperiodontitisradiotherapy

Identifiers

PMID38275388
PMCPMC10813307

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.